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jdispatcher-Viewer:序列相似性搜索结果和结构域预测的交互式可视化工具。

jdispatcher-viewers: interactive visualizations of sequence similarity search results and domain predictions.

作者信息

Madeira Fábio, Lee Joonheung, Madhusoodanan Nandana, Eusebi Alberto, Niewielska Ania, Butcher Sarah

机构信息

European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom.

出版信息

Bioinform Adv. 2025 May 23;5(1):vbaf122. doi: 10.1093/bioadv/vbaf122. eCollection 2025.

Abstract

MOTIVATION

Biological visualization is an important technique for researchers to make sense of complex biological data. Functional prediction and the discovery of novel proteins remain central objectives in biology, as they provide insights into molecular mechanisms with significant applications in health and disease. Visualizing sequence similarity search results and domain predictions is essential for exploring protein function, identifying conserved elements, and drawing meaningful connections between sequences, ultimately accelerating discovery.

RESULTS

The new website for the EMBL-EBI Job Dispatcher bioinformatics tools framework, was released in 2023. Along with improvements and new features, the website has since integrated interactive visualizations designed to aid researchers further and enrich the user experience. Here, we describe jdispatcher-viewers, a library for the interactive visualization of sequence similarity search results from BLAST and FASTA, and interactive visualizations of domain predictions and annotations provided by InterPro.

AVAILABILITY AND IMPLEMENTATION

The jdispatcher-viewers library and documentation which includes a demo webpage are available from https://github.com/ebi-jdispatcher/jdispatcher-viewers. Interactive visualizations provided among the result pages of sequence similarity search tools in Job Dispatcher have been implemented using jdispatcher-viewers, and are available at https://www.ebi.ac.uk/jdispatcher/sss. The library is distributed under the Apache 2.0 license.

摘要

动机

生物可视化是研究人员理解复杂生物数据的一项重要技术。功能预测和新蛋白质的发现仍然是生物学的核心目标,因为它们能深入了解分子机制,在健康和疾病方面有重要应用。可视化序列相似性搜索结果和结构域预测对于探索蛋白质功能、识别保守元件以及在序列之间建立有意义的联系至关重要,最终可加速发现进程。

结果

欧洲生物信息研究所(EMBL-EBI)作业调度器生物信息学工具框架的新网站于2023年发布。除了改进和新功能外,该网站此后还集成了交互式可视化,旨在进一步帮助研究人员并丰富用户体验。在此,我们描述了jdispatcher-viewers,这是一个用于交互式可视化来自BLAST和FASTA的序列相似性搜索结果以及InterPro提供的结构域预测和注释的库。

可用性和实现方式

jdispatcher-viewers库及包含演示网页的文档可从https://github.com/ebi-jdispatcher/jdispatcher-viewers获取。作业调度器中序列相似性搜索工具结果页面提供的交互式可视化已使用jdispatcher-viewers实现,可在https://www.ebi.ac.uk/jdispatcher/sss获取。该库根据Apache 2.0许可进行分发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdf7/12133269/4216e6dcda1d/vbaf122f1.jpg

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