Isoaspartate Repair of TGF- β Receptor 2 : A Novel Checkpoint in Kidney Fibrosis.
作者信息
Kuppe Christoph
机构信息
Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
出版信息
J Am Soc Nephrol. 2025 Jun 4;36(7):1238-1240. doi: 10.1681/ASN.0000000757.
Abstract
摘要
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本文引用的文献
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Kidney fibrosis: from mechanisms to therapeutic medicines.肾脏纤维化：从机制到治疗药物。
Signal Transduct Target Ther. 2023 Mar 17;8(1):129. doi: 10.1038/s41392-023-01379-7.
3
Decoding myofibroblast origins in human kidney fibrosis.解析人肾纤维化中肌成纤维细胞的起源。
Nature. 2021 Jan;589(7841):281-286. doi: 10.1038/s41586-020-2941-1. Epub 2020 Nov 11.
4
Diverse Role of TGF-β in Kidney Disease.转化生长因子-β在肾脏疾病中的多种作用
Front Cell Dev Biol. 2020 Feb 28;8:123. doi: 10.3389/fcell.2020.00123. eCollection 2020.
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Deficiency of protein-L-isoaspartate (D-aspartate) -methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma.内质网应激下蛋白质-L-异天冬氨酸（D-天冬氨酸）-甲基转移酶表达缺失促进肺腺癌上皮-间质转化。
Oncotarget. 2018 Jan 27;9(17):13287-13300. doi: 10.18632/oncotarget.24324. eCollection 2018 Mar 2.
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Renal fibrosis: Primacy of the proximal tubule.肾纤维化：近端小管的首要地位。
Matrix Biol. 2018 Aug;68-69:248-262. doi: 10.1016/j.matbio.2018.02.006. Epub 2018 Feb 6.
7
TGF-β: the master regulator of fibrosis.TGF-β：纤维化的主调控因子。
Nat Rev Nephrol. 2016 Jun;12(6):325-38. doi: 10.1038/nrneph.2016.48. Epub 2016 Apr 25.
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Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker.基于组织转录组学驱动鉴定表皮生长因子作为慢性肾脏病生物标志物
Sci Transl Med. 2015 Dec 2;7(316):316ra193. doi: 10.1126/scitranslmed.aac7071.
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Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.在产生基质的间质细胞中阻断转化生长因子-β信号传导并不能减轻肾纤维化。
Kidney Int. 2015 Sep;88(3):503-14. doi: 10.1038/ki.2015.51. Epub 2015 Mar 11.
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