Eriksson E, Jansson J O
Life Sci. 1985 Sep 30;37(13):1241-8. doi: 10.1016/0024-3205(85)90136-5.
The secretory pattern of growth hormone (GH) in female rats differs from that in males with respect to e.g. the inter-peak baseline levels being higher in females. In the present study the influence of sex steroids on plasma GH levels was investigated in male rats under various conditions. Administration of estradiol, but not testosterone, was found to increase GH release in rats with suppressed levels induced by exposure to swimming stress or by treatment with the monoamine depleting agent reserpine. In line with previous studies, administration of estradiol was found to increase also inter-peak GH levels in adult male rats; i.e. to cause a feminization of the secretory pattern. In stressed and in reserpinized animals as well as in normal male rats, the effect of estradiol is similar to that earlier demonstrated for somatostatin antiserum, and hence it is suggested that estradiol may act antagonistic to the GH inhibiting factor.
雌性大鼠生长激素（GH）的分泌模式与雄性不同，例如雌性的峰间基线水平较高。在本研究中，在各种条件下研究了性类固醇对雄性大鼠血浆GH水平的影响。发现给予雌二醇而非睾酮可增加因暴露于游泳应激或用单胺耗竭剂利血平治疗而导致GH水平受到抑制的大鼠的GH释放。与先前的研究一致，发现给予雌二醇也会增加成年雄性大鼠的峰间GH水平；即导致分泌模式女性化。在应激和利血平化的动物以及正常雄性大鼠中，雌二醇的作用与先前对生长抑素抗血清所证明的作用相似，因此表明雌二醇可能对GH抑制因子起拮抗作用。
