Avisar Hila, Greenbaum Uri, Djaldetti Ruth, Lerner Boaz
Department of Industrial Engineering & Management, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Neurological Institute, Division of Movement Disorders, Tel-Aviv Souraski Medical Center, Tel Aviv, Israel.
NPJ Parkinsons Dis. 2025 Jun 4;11(1):147. doi: 10.1038/s41531-025-01003-1.
Investigating the association between metabolic syndrome (MetS) and all its components with prediagnostic Parkinson's disease (PD) may clarify PD pathogenesis and identify candidates for prevention strategies and neuroprotective trials. We conducted a retrospective study of 890 PD patients diagnosed during 2000-2020 and 8,100 matched controls, analyzing electronic health records up to 15 years before PD diagnosis. Prevalence was assessed annually to track changes in association strength over time. PD patients consistently showed lower MetS prevalence (OR = 0.57-0.8). Compared to controls, PD patients had lower triglycerides (OR = 0.44-0.75), BMI (OR = 0.54-0.65), and hyperglycemia (OR = 0.81-0.86) rates, and females showed higher high-density lipoprotein (HDL) (OR = 1.48-1.82), lower low-density lipoprotein/HDL ratio (OR = 0.46-0.64), and reduced hypertension (OR = 0.79-0.85). These findings suggest an inverse association between MetS and PD years before diagnosis. We propose a lipid-blood pressure index incorporating triglycerides, HDL, and hypertension as a potential clinical tool for PD risk stratification.
研究代谢综合征（MetS）及其所有组分与帕金森病（PD）诊断前的关联，可能会阐明PD的发病机制，并确定预防策略和神经保护试验的候选对象。我们对2000年至2020年期间诊断的890例PD患者和8100例匹配对照进行了一项回顾性研究，分析了PD诊断前长达15年的电子健康记录。每年评估患病率，以追踪关联强度随时间的变化。PD患者的MetS患病率始终较低（OR = 0.57 - 0.8）。与对照组相比，PD患者的甘油三酯（OR = 0.44 - 0.75）、体重指数（BMI）（OR = 0.54 - 0.65）和高血糖（OR = 0.81 - 0.86）发生率较低，女性的高密度脂蛋白（HDL）较高（OR = 1.48 - 1.82），低密度脂蛋白/HDL比值较低（OR = 0.46 - 0.64），高血压发生率降低（OR = 0.79 - 0.85）。这些发现表明，在诊断前数年，MetS与PD之间存在负相关。我们提出一种结合甘油三酯、HDL和高血压的脂质 - 血压指数，作为PD风险分层的潜在临床工具。
