Shionozaki Moyuru, Yamamoto Ryo, Hamano Jun
Department of General Practice, Saku Central Hospital, 197 Usuda, Saku, Nagano, Japan.
Department of Palliative Medicine, Saku Central Hospital Advanced Care Center, 3400-28 Nakagomi, Saku, Nagano, Japan.
BMC Palliat Care. 2025 Jun 4;24(1):158. doi: 10.1186/s12904-025-01799-y.
Previous studies have investigated the frequency and target symptoms of palliative sedation in patients with home-based cancer. However, the status of home-based non-cancer patients remains unclear. This study aimed to determine the frequency and target symptoms of palliative sedation in home-based non-cancer patients in Japan.
We conducted a post hoc analysis of a multicenter prospective cohort study of elderly non-cancer patients at home in Japan between January 2020 and December 2020. The physicians routinely assessed and recorded symptoms and treatment every 3 months until home care was discontinued or until the patient died at home. This multicenter prospective cohort study targeted non-cancer patients aged 65 years and over receiving care at home or in nursing homes.
Of the 785 patients, 195 died at home or in nursing homes. Seven patients (3.6%) received palliative sedation before death. The target symptoms for sedation were delirium and dyspnea.
The sedation rate for noncancer patients at home is relatively low, and the major target symptoms of sedation are delirium and dyspnea.
既往研究已对居家癌症患者姑息性镇静的频率及目标症状进行了调查。然而，居家非癌症患者的情况仍不明确。本研究旨在确定日本居家非癌症患者姑息性镇静的频率及目标症状。
我们对2020年1月至2020年12月期间在日本进行的一项针对居家老年非癌症患者的多中心前瞻性队列研究进行了事后分析。医生每3个月定期评估并记录症状及治疗情况，直至居家护理停止或患者在家中死亡。这项多中心前瞻性队列研究的对象是年龄在65岁及以上、在家中或养老院接受护理的非癌症患者。
785例患者中，195例在家中或养老院死亡。7例患者（3.6%）在死亡前接受了姑息性镇静。镇静的目标症状为谵妄和呼吸困难。
居家非癌症患者的镇静率相对较低，镇静的主要目标症状为谵妄和呼吸困难。
