通过封装提高Cu(I)-NHC配合物在生物介质中的铜催化叠氮-炔环加成反应效率。
Enhancing the CuAAC efficiency of a Cu(I)-NHC complex in biological media by encapsulation.
作者信息
Prakasham A P, Singh Harshit, Palmans Anja R A
机构信息
Department of Chemical Engineering & Chemistry and Institute for Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.
出版信息
Chem Commun (Camb). 2025 Jun 5. doi: 10.1039/d5cc01891a.
A novel [(NHC)Cu]Br (Cu(I)-NHC) complex promotes CuAAC reactions in organic solvents, water, buffers and even complex biological media in good yields. Encapsulation of the Cu catalyst in an amphiphilic polymer enhances its performance in complex media, increases catalyst stability in the presence of glutathione and reduces cytotoxicity in HeLa cells.
一种新型的[(NHC)Cu]Br（Cu(I)-NHC）配合物能在有机溶剂、水、缓冲液甚至复杂的生物介质中高效促进铜催化的叠氮-炔环加成（CuAAC）反应。将铜催化剂封装在两亲性聚合物中可提高其在复杂介质中的性能，增强其在谷胱甘肽存在下的稳定性，并降低其对HeLa细胞的细胞毒性。
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