Doná Florencia, Lorenz Virginia, Stegmayer Georgina, Ricardo Tamara, D'Iorio Stefanía, Ponzo Fernando, Repetti María Rosa, Demonte Luisina Delma, Milesi María Mercedes, Varayoud Jorgelina
Instituto de Salud y Ambiente del Litoral (ISAL), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral (UNL) - Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Santa Fe, Argentina.
Cátedra de Fisiología Humana, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
Front Toxicol. 2025 May 21;7:1579952. doi: 10.3389/ftox.2025.1579952. eCollection 2025.
Despite accumulated evidence indicating glyphosate herbicide (GLY) presents endocrine disrupting properties, there are still discrepancies. Moreover, few epidemiological studies have focused on hormone-related pathologies. This work aimed to investigate the associations between urinary GLY levels and breast cancer (BC) in women from a region of intense agricultural activity in Argentina, exploring residential proximity to agricultural fields as a potential risk factor for BC. This was a case-control study that involved 90 women from different populations in the Province of Santa Fe, Argentina. Demographic data, lifestyle factors, and residential history were obtained through a questionnaire, while medical outcomes and reproductive history were acquired from medical records. Spot urine samples were collected and the concentrations of GLY and its primary metabolite, aminomethylphosphonic acid (AMPA) were quantified by ultra-high-performance liquid chromatography-mass spectrometry. Odds ratios were estimated to assess the strength of the association between the case/control type and each predictor. GLY concentrations were above the limit of detection (LOD) in 86.1% of samples, with a range of 0.37-10.07 µg GLY/g creatinine. AMPA was not detected in any of the samples analyzed. Although urinary GLY concentrations showed no differences between the case and control groups, women residing near agricultural fields showed an increased risk of BC (OR: 7.38, 95% CI: 2.74-21.90). These original findings show the ubiquitous presence of GLY in adult women from Argentina. Interestingly, women living near agricultural fields have a higher risk of BC, suggesting that exposure not only to GLY but also to agrochemicals in general, could predispose to the development of BC in Argentina. While this study provides valuable insights, further and broader assessments of BC distribution in relation to agrochemical exposure acroos different regions of Argentina are needed.
尽管有越来越多的证据表明草甘膦除草剂（GLY）具有内分泌干扰特性，但仍存在争议。此外，很少有流行病学研究关注与激素相关的疾病。这项研究旨在调查阿根廷一个农业活动频繁地区女性尿液中GLY水平与乳腺癌（BC）之间的关联，探讨居住在农田附近是否为BC的潜在风险因素。这是一项病例对照研究，涉及来自阿根廷圣菲省不同人群的90名女性。通过问卷调查获取人口统计学数据、生活方式因素和居住史，同时从医疗记录中获取医疗结果和生殖史。收集即时尿样，采用超高效液相色谱-质谱法定量测定GLY及其主要代谢产物氨基甲基膦酸（AMPA）的浓度。估计比值比以评估病例/对照类型与每个预测因素之间关联的强度。86.1%的样本中GLY浓度高于检测限（LOD），范围为0.37 - 10.07 μg GLY/g肌酐。在所分析的任何样本中均未检测到AMPA。尽管病例组和对照组的尿液GLY浓度无差异，但居住在农田附近的女性患BC的风险增加（比值比：7.38，95%置信区间：2.74 - 21.90）。这些初步研究结果表明GLY在阿根廷成年女性中普遍存在。有趣的是
