Qi Dingtian, Wang Bowen, Zhang Haoxun, Xiong Feng, Zhang Guoling, Wang Chunyang
The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Prev Med Rep. 2025 May 2;54:103096. doi: 10.1016/j.pmedr.2025.103096. eCollection 2025 Jun.
This study aimed to evaluate the epidemiological burden and temporal trends of kidney cancer (KC) attributable to smoking from 1990 to 2021.
The study included 204 countries and regions, as provided in the 2021 Global Burden of Disease (GBD) database. The study participants were patients with KC attributable to smoking. The Deaths, Disability-Adjusted Life Years (DALYs), Years Lived with Disability (YLDs), and Years of Life Lost (YLLs) were estimated.
In 2021, KC attributable to smoking caused 16,216.48(95 % UI:9662.84 to 23,217.42) deaths globally, with DALYs at 382927.14(95 % UI:233634.99 to 536,755.44), YLDs at 16,084.01(95 % UI:9290.43 to 25,354.68), and YLLs at 366,843.12(95 % UI:223833.69 to 513,164.93). From 1990 to 2021, the age-standardized rate (ASR) of disease indicators has declined globally, and middle-sociodemographic index (SDI) countries demonstrated the most substantial increase in ASRs for all indicators. The global number of DALYs has increased, with the most substantial increases occurring in high-middle SDI countries. The effective difference (EF) for all four disease indicators generally exhibited a spiraling expanding trend with increasing SDI. Predictive analysis suggests that the number of indicators will increase from 2022 to 2040, whereas ASR for these indicators is expected to decline annually through 2040.
The global burden of KC attributable to smoking remains substantial, particularly in high-SDI regions, especially among men. In recent years, Middle-SDI regions have exhibited the sharpest rise in disease burden, demanding continued focus. Addressing health outcomes solely through social development progress proves challenging,targeted strategies are essential.
本研究旨在评估1990年至2021年吸烟所致肾癌（KC）的流行病学负担和时间趋势。
该研究涵盖了2021年全球疾病负担（GBD）数据库中提供的204个国家和地区。研究对象为吸烟所致KC患者。对死亡人数、伤残调整生命年（DALYs）、带病生存年数（YLDs）和寿命损失年数（YLLs）进行了估计。
2021年，吸烟所致KC在全球造成16216.48例（95%不确定区间：9662.84至23217.42）死亡，DALYs为382927.14（95%不确定区间：233634.99至536755.44），YLDs为16084.01（95%不确定区间：9290.43至25354.68），YLLs为366843.12（95%不确定区间：223833.69至513164.93）。从1990年到2021年，全球疾病指标的年龄标准化率（ASR）有所下降，中等社会人口指数（SDI）国家在所有指标的ASR方面增幅最大。全球DALYs数量有所增加，在高中等SDI国家增加最为显著。所有四个疾病指标的有效差异（EF）总体上呈现出随着SDI增加而螺旋式扩大的趋势。预测分析表明，从2022年到2040年指标数量将增加，而这些指标的ASR预计到2040年每年都会下降。
吸烟所致KC的全球负担仍然很大，特别是在高SDI地区，尤其是在男性中。近年来，中等SDI地区疾病负担上升最为明显，需要持续关注。仅通过社会发展进步来解决健康问题具有挑战性，针对性策略至关重要。
