Li Hao, Li Xin, Li JinYu, Ma YuMeng, Li Gang
Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Front Endocrinol (Lausanne). 2025 May 21;16:1486633. doi: 10.3389/fendo.2025.1486633. eCollection 2025.
To investigate whether seasonal variations and meteorological factors influence pregnancy outcomes in women undergoing fertilization/Intracytoplasmic sperm injection and embryo transfer(IVF/ICSI-ET) treatment.
We conducted a retrospective cohort study of women who underwent IVF/ICIS-ET for the first time at the Reproductive Medicine Center of the First Affiliated Hospital of Zhengzhou University from January 1, 2011, to December 1, 2021. A total of 24420 cycles were collected. They were divided into four groups according to the oocyte retrieval date. The main outcome measures were clinical pregnancy rate and live birth rate. Binary logistic regression was used to explore the factors affecting clinical pregnancy rate and live birth rate.
In this study, the live birth rate of cycles with oocyte retrieval performed in summer was significantly higher than those in spring, autumn, and winter (61.24% [4859/7934] vs. 59.09% [3074/5202] vs. 58.89% [3676/6242] vs. 57.70% [2909/5042]; <0.001), with the summer group also exhibiting the lowest abortion rate among the four seasons. Notably, despite these differences, no statistically significant variations were observed in biochemical pregnancy rates or clinical pregnancy rates across the groups (>0.05). Taking spring as the reference, the live birth rate in summer was higher (aOR=1.079,95% CI: 1.004-1.160), and the abortion rate was lower (aOR = 0.841,95% CI: 0.746-0.948). The live birth rate and abortion rate in autumn and winter were not significantly different from spring. Multivariate logistic regression analysis showed higher daily average temperature, and humidity at the time of oocyte retrieval increased the live birth rate (OR = 1.005, 95% CI = 1.002-1.007; OR = 1.004, 95% CI = 1.001-1.006).
In women who undergo IVF/ICSI treatment, the season ambient temperature, and humidity on the date of the oocyte retrieval may impact embryo development and live birth.
探讨季节变化和气象因素是否会影响接受体外受精/卵胞浆内单精子注射及胚胎移植（IVF/ICSI-ET）治疗的女性的妊娠结局。
我们对2011年1月1日至2021年12月1日在郑州大学第一附属医院生殖医学中心首次接受IVF/ICIS-ET治疗的女性进行了一项回顾性队列研究。共收集了24420个周期。根据取卵日期将其分为四组。主要观察指标为临床妊娠率和活产率。采用二元逻辑回归分析探讨影响临床妊娠率和活产率的因素。
在本研究中，夏季取卵周期的活产率显著高于春季、秋季和冬季（61.24%[4859/7934]对59.09%[3074/5202]对58.89%[3676/6242]对57.70%[2909/5042]；<0.001），夏季组在四个季节中的流产率也最低。值得注意的是，尽管存在这些差异，但各组之间的生化妊娠率或临床妊娠率均未观察到统计学上的显著差异（>0.05）。以春季为参照，夏季的活产率更高（调整后比值比[aOR]=1.079，95%置信区间[CI]：1.004-1.160），流产率更低（aOR = 0.841，95%CI：0.746-0.948）。秋季和冬季的活产率及流产率与春季无显著差异。多因素逻辑回归分析显示，取卵时的日平均气温较高以及湿度增加会提高活产率（比值比[OR]=1.005，95%CI = 1.002-1.007；OR = 1.004，95%CI = 1.001-1.006）。
在接受IVF/ICSI治疗的女性中，取卵日期的季节、环境温度和湿度可能会影响胚胎发育和活产情况。
