45S5 生物活性玻璃对牙本质人工龋的再矿化作用。
Remineralising effect of 45S5 bioactive glass on artificial caries in dentine.
机构信息
Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Department of Polyclinics, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
出版信息
BMC Oral Health. 2020 Feb 11;20(1):49. doi: 10.1186/s12903-020-1038-4.
BACKGROUND
This study investigated the remineralisation effect of bioactive glass on artificial dentine caries.
METHODS
Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.
RESULTS
AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and - 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively.
CONCLUSION
Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.
背景
本研究旨在探讨生物活性玻璃对人工牙本质龋的再矿化效果。
方法
用生物活性玻璃（BAG 组）、酪蛋白磷酸肽-无定形磷酸钙（CPP-ACP 组）、氟化钠甘油（F 组）或去离子水（W 组）处理有牙本质龋的牙本质圆盘。所有圆盘随后均进行 pH 循环 28 天。采用原子力显微镜（AFM）、显微硬度测试和共聚焦激光扫描显微镜（CLSM）分别评估牙本质龋损的形貌、显微硬度和再矿化深度。
结果
AFM 图像显示 BAG 组牙本质龋表面有矿物质沉积。pH 循环后维氏硬度值（ΔVHN，均值±标准差）的变化分别为 9.67±3.60、6.06±3.83、5.00±2.19 和-1.90±2.09（p<0.001），BAG 组、CPP-ACP 组、F 组和 W 组。BAG 组、CPP-ACP 组、F 组和 W 组牙本质龋的再矿化深度（均值±标准差）分别为 165±11μm、111±11μm、75±6μm 和 0μm（p<0.001）。
结论
生物活性玻璃对人工牙本质龋具有良好的再矿化效果，可能是龋病治疗的一种选择。
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