Chrabaszcz Anna, Fiez Julie A
University of Pittsburgh.
Res Sq. 2025 May 16:rs.3.rs-6614964. doi: 10.21203/rs.3.rs-6614964/v1.
This study examined the impact of cerebellar stroke on both well-established reading skills and emergent literacy abilities using a combination of static and dynamic assessments. The static component involved a lexical decision task featuring novel orthographic forms (pseudowords) followed by tests of orthographic memory. The dynamic component employed a training protocol in an artificial orthography, requiring participants to learn new grapheme-phoneme correspondences and read in a novel script. Participants included individuals with cerebellar stroke (n = 13) and demographically matched controls (n = 13). Results indicated that cerebellar damage impairs phonological decoding processes, disrupting both reading of novel forms in a familiar orthography and the acquisition of new orthographic-phonological mappings. Notably, five of the 13 cerebellar patients met criteria for phonological alexia, though no clear relationship emerged between symptom severity and lesion characteristics. These findings underscore the cerebellum's role in phonological decoding and its contribution to both established and emergent aspects of reading.
本研究使用静态和动态评估相结合的方法，考察了小脑中风对已确立的阅读技能和新兴读写能力的影响。静态部分包括一个以新颖拼写形式（假词）为特征的词汇判断任务，随后是拼写记忆测试。动态部分采用了一种人工拼写的训练方案，要求参与者学习新的字素-音素对应关系，并阅读一种新颖的文字。参与者包括小脑中风患者（n = 13）和人口统计学匹配的对照组（n = 13）。结果表明，小脑损伤会损害语音解码过程，扰乱熟悉拼写法中对新颖形式的阅读以及新的拼写-语音映射的习得。值得注意的是，13名小脑中风患者中有5名符合语音失读症的标准，尽管症状严重程度与病变特征之间没有明显的关系。这些发现强调了小脑在语音解码中的作用及其对阅读的既定方面和新兴方面的贡献。
