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喹喔啉-1,4-二氧化物型促生长剂的细胞遗传学效应。III. 小鼠经胎盘微核试验

Cytogenetic effects of quinoxaline-1,4-dioxide-type growth-promoting agents. III. Transplacental micronucleus test in mice.

作者信息

Cihák R, Vontorková M

出版信息

Mutat Res. 1985 Oct;144(2):81-4. doi: 10.1016/0165-7992(85)90006-5.

DOI:10.1016/0165-7992(85)90006-5
PMID:4047074
Abstract

The growth-promoting agents carbadox and olaquindox were active in the mouse transplacental micronucleus test, whereas cyadox was ineffective. Chemicals were administered p.o. and i.p. at a dose of 100 mg/kg and the effect was observed 18 h after treatment. The effects observed in fetal liver were parallel to those in maternal bone marrow, but fetal tissue was approximately 2-3 times more sensitive.

摘要

促生长剂卡巴氧和喹乙醇在小鼠经胎盘微核试验中具有活性,而喹赛多则无效。化学物质经口和腹腔注射给药,剂量为100mg/kg,并在治疗后18小时观察效果。在胎儿肝脏中观察到的效果与母体骨髓中的效果相似,但胎儿组织的敏感性约高2至3倍。

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