Cihák R, Srb V
Mutat Res. 1983 Feb;116(2):129-35. doi: 10.1016/0165-1218(83)90103-9.
The cytogenetic activities of 3 growth-promoting agents carbadox, olaquindox and cyadox were examined by the micronucleus test. These chemicals were administered i.p. to male Wistar rats 30 and 6 h before they were killed. Single-dose levels were 5, 10, 15, 30, 60, 90, 120 and 240 mg/kg for carbadox; 30, 60, 90, 120 and 240 mg/kg for olaquindox; and for cyadox 30, 60, 120 and 240 mg/kg. Over the entire dose range tested, carbadox induced a statistically significant increase in the number of micronucleated polychromatic erythrocytes in the rat bone marrow, whereas similar activity of olaquindox started at a dose of 2 X 60 mg/kg. The effect of cyadox was very low even at the highest dosage tested. Further testing of the genotoxicity of this class of chemicals is required. The genetic activity of the solvent used (dimethyl sulfoxide) is briefly discussed.
通过微核试验检测了3种促生长剂卡巴氧、喹乙醇和环丙氨嗪的细胞遗传学活性。在处死雄性Wistar大鼠前30小时和6小时，将这些化学物质腹腔注射给大鼠。卡巴氧的单剂量水平为5、10、15、30、60、90、120和240mg/kg；喹乙醇为30、60、90、120和240mg/kg；环丙氨嗪为30、60、120和240mg/kg。在整个测试剂量范围内，卡巴氧可使大鼠骨髓中含微核的多染性红细胞数量出现统计学上的显著增加，而喹乙醇在剂量为2×60mg/kg时才开始出现类似活性。即使在测试的最高剂量下，环丙氨嗪的作用也非常低。需要对这类化学物质的遗传毒性进行进一步测试。文中简要讨论了所用溶剂（二甲基亚砜）的遗传活性。
