Heydarazad Zadeh Maryam, Mahdaviani Seyed Alireza, Eslaminejad Alireza, Rekabi Mahsa
Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Allergy Asthma Immunol. 2025 May 5;24(3):277-282. doi: 10.18502/ijaai.v24i3.18678.
Measuring the performance of small airways dysfunction is challenging due to their relative inaccessibility with conventional methods. In recent years, spirometry and impulse oscillometry (IOS) methods have been widely used for their evaluation. The aim of this study was to investigate the relationship between spirometric parameters and IOS in newly diagnosed asthma (NDA) patients. In this cross-sectional study, 100 NDA patients who referred to the allergy Clinic of Masih Daneshvari Hospital between 2021 and 2023 were enrolled. IOS and spirometry tests were performed for all patients. Spirometry measures included forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC, and forced expiratory flow (FEF25-75). IOS criteria included R5%, R20%, R5-R20%, X5%, Ax% and FRES. The relationship between spirometry and IOS parameters was evaluated. The mean age was 22.6±9.5 years. None of the 2 techniques had a significant relationship with disease severity. FVC, FEV1/FVC and FEF25-75 indices had a significant positive correlation with all other IOS indices except for Ax. In the comparison of FEF25-75 parameter in spirometry, 4 IOS indices including R5, R20, R5-R20 and X5 had appropriate sensitivity and specificity for predicting asthma. In the comparison of FEF25-75 parameter in spirometry, 4 IOS indices including R5, R20, R5-R20 and X5 had appropriate sensitivity and specificity for predicting asthma. The sensitivity and specificity of R5 for asthma diagnosis were 0.85 and 0.73, respectively. Further multicenter studies with larger sample sizes are recommended to confirm these results.
由于传统方法相对难以触及小气道，因此测量小气道功能障碍的表现具有挑战性。近年来，肺量计和脉冲振荡法（IOS）已被广泛用于其评估。本研究的目的是调查新诊断哮喘（NDA）患者的肺量计参数与IOS之间的关系。在这项横断面研究中，纳入了2021年至2023年间转诊至马西·达内什瓦里医院过敏诊所的100例NDA患者。对所有患者进行了IOS和肺量计测试。肺量计测量包括用力肺活量（FVC）、第一秒用力呼气量（FEV1）、FEV1/FVC和用力呼气流量（FEF25-75）。IOS标准包括R5%、R20%、R5-R20%、X5%、Ax%和FRES。评估了肺量计和IOS参数之间的关系。平均年龄为22.6±9.5岁。这两种技术均与疾病严重程度无显著关系。FVC、FEV1/FVC和FEF25-75指数与除Ax之外的所有其他IOS指数均呈显著正相关。在肺量计中FEF25-75参数的比较中，包括R5、R20、R5-R20和X5在内的4个IOS指数对预测哮喘具有适当的敏感性和特异性。在肺量计中FEF25-75参数的比较中,包括R5、R20、R5-R20和X5在内的4个IOS指数对预测哮喘具有适当的敏感性和特异性。R5诊断哮喘的敏感性和特异性分别为0.85和0.73。建议进行进一步的多中心、大样本量研究以证实这些结果。
