Gooskens R H, Willemse J, Gielen C
Neuropediatrics. 1985 Aug;16(3):115-20. doi: 10.1055/s-2008-1052554.
In the study of cerebrospinal fluid dynamics in children with macrocephaly, the lumbar CSF infusion technique has always been used. Previous studies showed, that the regulation of cerebrospinal fluid dynamics are mainly determined by Pressure-Volume Index (PVI) and outflow resistance (Ro). Recent studies have shown, that the relationship between pressure and volume is mono exponential with a constant. This result suggests a third parameter c. PVI, Ro and c were determined with a combination of bolusmethod and a constant flow infusion.
在对巨头症患儿脑脊液动力学的研究中,一直采用腰椎脑脊液输注技术。先前的研究表明,脑脊液动力学的调节主要由压力-容量指数(PVI)和流出阻力(Ro)决定。最近的研究表明,压力与容量之间的关系是具有一个常数的单指数关系。这一结果提示了第三个参数c。通过推注法和恒流输注相结合的方法测定了PVI、Ro和c。