Wauquier A, Edmonds H L, Van den Broeck W A, Melis W, Van Loon J
Neuropsychobiology. 1985;13(3):147-51. doi: 10.1159/000118178.
A 10-min cardiac arrest was produced in alfentanil-anesthetised dogs by electrical fibrillation of the heart. Recovery of cerebral function was monitored by 3 separate EEG techniques and visual assessment of neurologic deficit. The EEG techniques were visual scoring, broad-band power spectral analysis and period-amplitude analysis. The treatment group (n = 8) received flunarizine (0.1 mg/kg i.v.) at the beginning of resuscitation, while control animals (n = 8) were given the drug vehicle. A significant improvement in the visual EEG score and neurologic deficit 6 h after insult was noted in flunarizine-treated dogs. The extent of neurologic recovery was significantly correlated with the visual EEG score, with the relative power in the alpha frequency band (7.5-13.5 c/s) and with the percentage of zero-cross frequency.
通过心脏电颤动在接受阿芬太尼麻醉的犬只中引发10分钟的心脏骤停。采用3种不同的脑电图技术以及对神经功能缺损的视觉评估来监测脑功能的恢复情况。脑电图技术包括视觉评分、宽带功率谱分析和周期-振幅分析。治疗组（n = 8）在复苏开始时静脉注射氟桂利嗪（0.1 mg/kg），而对照组动物（n = 8）给予药物赋形剂。在氟桂利嗪治疗的犬只中，损伤后6小时脑电图视觉评分和神经功能缺损有显著改善。神经功能恢复程度与脑电图视觉评分、α频段（7.5 - 13.5 c/s）的相对功率以及过零频率百分比显著相关。
