White B C, Gadzinski D S, Hoehner P J, Krome C, Hoehner T, White J D, Trombley J H
Ann Emerg Med. 1982 Mar;11(3):119-26. doi: 10.1016/s0196-0644(82)80235-7.
Twelve dogs were anesthetized and instrumental for determination of CVP, arterial pressure, intracranial pressure, left atrial pressure, and frontal cerebral cortical blood flow (CCBF) by the thermal method. A catheter was introduced into the venous return of the cerebral confluence to allow determination of cerebral A-V oxygen saturation differences. The animals were placed on cardiac bypass using a circuit from the right atrium to the pulmonary artery and a second circuit from the left ventricular apex to the left femoral artery. A heat exchanger was used to maintain a constant blood temperature of 37 C in the output of the left side bypass circuit. All animals were heparinized during bypass. Ventricular fibrillation was induced after completion of the bypass surgery. Two dogs served as controls. Pre-arrest determinations of hemoglobin, glucose, CCBF, and cerebral A-V oxygen differences were taken. Full circulatory arrest was carried out for 20 minutes by shutting off the cardiac bypass. Resuscitation was achieved by resumption of bypass perfusion. Acid-base balance was corrected quickly, and pre-arrest perfusion pressure was achieved and maintained for 90 minutes. All pressure parameters were monitored continuously. All pre-arrest determinations were repeated at 20, 40, 60, and 90 minutes post resuscitation. Five dogs were treated with 6 microgram/kg flunarizine administered IV drip over 10 minutes immediately post reperfusion. Five dogs were not treated post arrest. Treated animals had a prompt return of CCBF rates equal to or greater than pre-arrest flow, which persisted throughout the period of post-arrest observation. Untreated animals had markedly reduced CCBF and increased resistance. CCBF uniformly proceeded to near zero flow by 90 minutes. The ICP was not significantly altered by treatment.
12只狗被麻醉并通过仪器测定中心静脉压（CVP）、动脉压、颅内压、左心房压以及采用热法测定额叶脑皮质血流量（CCBF）。将一根导管插入脑静脉汇合处的静脉回流中，以测定脑动静脉血氧饱和度差。使用从右心房到肺动脉的回路以及从左心室尖到左股动脉的第二个回路，使动物处于体外循环状态。使用热交换器将左侧旁路回路输出端的血液温度维持在37℃恒定。在体外循环期间所有动物均接受肝素化处理。在旁路手术后诱发心室颤动。2只狗作为对照。在心脏停搏前测定血红蛋白、葡萄糖、CCBF以及脑动静脉血氧差。通过关闭体外循环进行20分钟的完全循环停搏。通过恢复旁路灌注实现复苏。迅速纠正酸碱平衡，并达到并维持心脏停搏前的灌注压90分钟。持续监测所有压力参数。在复苏后20、40、60和90分钟重复所有心脏停搏前的测定。5只狗在再灌注后立即通过静脉滴注给予6微克/千克氟桂利嗪，持续10分钟。5只狗在心脏停搏后未接受治疗。接受治疗的动物CCBF速率迅速恢复至等于或大于心脏停搏前的血流水平，并在心脏停搏后的观察期内一直保持。未接受治疗的动物CCBF明显降低且阻力增加。到90分钟时CCBF均降至接近零流量。治疗对颅内压无显著影响。
