热休克蛋白在衰老和慢性炎症性疾病中的作用。
Role of heat shock proteins in aging and chronic inflammatory diseases.
机构信息
Department of Pathology, University of Mississippi Medical Cent, er, 2500 N. State St, Jackson, MS, 39216, USA.
Department of Radiation Oncology, University of Mississippi Medical Center, 2500 N. State St, Jackson, MS, 39216, USA.
出版信息
Geroscience. 2021 Oct;43(5):2515-2532. doi: 10.1007/s11357-021-00394-2. Epub 2021 Jul 9.
Advanced age is associated with a decline in response to stress. This contributes to the establishment of chronic inflammation, one of the hallmarks of aging and age-related disease. Heat shock proteins (HSP) are determinants of life span, and their progressive malfunction leads to age-related pathology. To discuss the function of HSP on age-related chronic inflammation and illness. An updated review of literature and discussion of relevant work on the topic of HSP in normal aging and chronic inflammatory pathology was performed. HSP contribute to inflamm-aging. They also play a key role in age-associated pathology linked to chronic inflammation such as autoimmune disorders, neurological disease, cardiovascular disorder, and cancer. HSP may be targeted for control of their effects related to age and chronic inflammation. Research on HSP functions in age-linked chronic inflammatory disorders provides an opportunity to improve health span and delay age-related chronic disorders.
高龄与应激反应能力下降有关。这导致了慢性炎症的产生，而慢性炎症是衰老和与年龄相关疾病的特征之一。热休克蛋白（HSP）是决定寿命的因素，其逐渐发生故障会导致与年龄相关的病理。讨论 HSP 对与年龄相关的慢性炎症和疾病的作用。对 HSP 在正常衰老和慢性炎症病理中的作用进行了文献更新综述和相关工作的讨论。HSP 有助于促炎性衰老。它们在与慢性炎症相关的与年龄相关的病理中也起着关键作用，如自身免疫性疾病、神经退行性疾病、心血管疾病和癌症。可以针对 HSP 进行靶向治疗，以控制其与年龄和慢性炎症相关的作用。研究 HSP 在与年龄相关的慢性炎症性疾病中的功能为改善健康寿命和延缓与年龄相关的慢性疾病提供了机会。
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