Parvalbumin and vitamin D-dependent calcium-binding protein (Mr 28,000): comparison of their localization in the cerebellum of normal and rachitic rats.

Two neuronal and Ca2+-binding proteins, parvalbumin and a vitamin-D-dependent calcium-binding protein (CaBP; Mr = 28,000) were localized immunohistochemically in the rat cerebellum, which is the brain region containing the highest concentration of them both. Parvalbumin was present in Purkinje, basket and stellate cells of the molecular layer, whereas CaBP was only present in Purkinje cells. The concentrations of both proteins, measured immunohistochemically and biochemically, were unaffected by the vitamin D status of the rats.