维生素D过量中毒的大鼠尾状壳核中parvalbumin增加。
Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis.
作者信息
de Viragh P A, Haglid K G, Celio M R
机构信息
Institute of Anatomy, University of Zürich, Switzerland.
出版信息
Proc Natl Acad Sci U S A. 1989 May;86(10):3887-90. doi: 10.1073/pnas.86.10.3887.
Abstract
The influence of chronic vitamin D3 application on the concentration of the four calcium-binding proteins parvalbumin, the 28-kDa calbindin-D, calmodulin, and S-100 was studied in various brain regions and in the kidney. Young rats were administered daily 20,000 international units of vitamin D3 per kg (body weight) over a period of 4 months. This chronic treatment resulted in a clinically mild hypervitaminosis that did not affect the content of calmodulin, the 28-kDa calbindin-D, and S-100. Also the concentration of parvalbumin in the cerebral cortex, hippocampus, and kidney remained unchanged. On the other hand, parvalbumin was increased about 50% in the caudate putamen of hypervitaminotic animals as compared to controls. Our results indicate that the metabolism of parvalbumin in the caudate putamen can be influenced by variations of the blood level of this steroid hormone.
摘要
研究了长期应用维生素D3对不同脑区和肾脏中四种钙结合蛋白（小白蛋白、28 kDa钙结合蛋白-D、钙调蛋白和S-100）浓度的影响。给幼鼠连续4个月每日按每千克（体重）20,000国际单位的剂量给予维生素D3。这种长期治疗导致临床上轻度维生素过多症，但未影响钙调蛋白、28 kDa钙结合蛋白-D和S-100的含量。大脑皮质、海马体和肾脏中小白蛋白的浓度也保持不变。另一方面，与对照组相比，维生素过多症动物的尾状壳核中小白蛋白增加了约50%。我们的结果表明，尾状壳核中小白蛋白的代谢会受到这种甾体激素血液水平变化的影响。
相似文献
1
Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis.维生素D过量中毒的大鼠尾状壳核中parvalbumin增加。
Proc Natl Acad Sci U S A. 1989 May;86(10):3887-90. doi: 10.1073/pnas.86.10.3887.
2
Calmodulin binding to the intestinal brush-border membrane: comparison to other calcium-binding proteins.钙调蛋白与小肠刷状缘膜的结合：与其他钙结合蛋白的比较。
Biochim Biophys Acta. 1989 Jan 17;1010(1):122-7. doi: 10.1016/0167-4889(89)90192-4.
3
Developmental appearance of the Ca2+-binding proteins parvalbumin, calbindin D-28K, S-100 proteins and calmodulin during testicular development in the rat.
Cell Tissue Res. 1988 May;252(2):359-65. doi: 10.1007/BF00214378.
4
Parvalbumin and vitamin D-dependent calcium-binding protein (Mr 28,000): comparison of their localization in the cerebellum of normal and rachitic rats.小白蛋白与维生素D依赖性钙结合蛋白（分子量28,000）：它们在正常及佝偻病大鼠小脑定位的比较
Neurosci Lett. 1985 Aug 16;59(1):97-103. doi: 10.1016/0304-3940(85)90221-6.
5
Distribution of calbindin D-28k and parvalbumin neurons and fibers in the rat basal ganglia.
Brain Res Bull. 1998 Sep 15;47(2):107-16. doi: 10.1016/s0361-9230(98)00035-5.
6
Postnatal development of parvalbumin-, calbindin- and adult GABA-immunoreactivity in two visual nuclei of zebra finches.斑胸草雀两个视觉核中微小清蛋白、钙结合蛋白和成年γ-氨基丁酸免疫反应性的出生后发育
Brain Res. 1988 Dec 20;475(2):205-17. doi: 10.1016/0006-8993(88)90609-9.
7
Non-serotonergic dorsal and median raphe projection onto parvalbumin- and calbindin-containing neurons in hippocampus and septum.非5-羟色胺能的背侧和中缝核向海马和隔区中含小白蛋白和钙结合蛋白的神经元的投射。
Neuroscience. 2004;124(3):573-81. doi: 10.1016/j.neuroscience.2003.12.020.
8
Cajal-Retzius neurons in developing monkey neocortex show immunoreactivity for calcium binding proteins.发育中的猴新皮层中的卡哈尔-雷茨乌斯神经元对钙结合蛋白呈免疫反应性。
J Neurocytol. 1990 Apr;19(2):200-12. doi: 10.1007/BF01217298.
9
Compartmentalization of calbindin and parvalbumin in different parts of rat rubrospinal neurons.
Neuroscience. 1996 Sep;74(2):427-34. doi: 10.1016/0306-4522(96)00154-6.
10
Co-operativity and calcium/magnesium binding to troponin C and muscle calcium binding parvalbumin: an hypothesis.协同性以及钙/镁与肌钙蛋白C和肌肉钙结合蛋白（小清蛋白）的结合：一种假说
J Theor Biol. 1980 Jun 7;84(3):401-44. doi: 10.1016/s0022-5193(80)80013-0.
引用本文的文献
1
Night shift work, poor sleep quality and unhealthy sleep behaviors are positively associated with the risk of epilepsy disease.夜班工作、睡眠质量差和不健康的睡眠行为与癫痫疾病的风险呈正相关。
BMC Public Health. 2024 Nov 29;24(1):3337. doi: 10.1186/s12889-024-20885-z.
2
Associations of vitamin D receptor polymorphisms with risk of Alzheimer's disease, Parkinson's disease, and mild cognitive impairment: a systematic review and meta-analysis.维生素D受体基因多态性与阿尔茨海默病、帕金森病及轻度认知障碍风险的关联：一项系统综述和荟萃分析
Front Aging Neurosci. 2024 Apr 12;16:1377058. doi: 10.3389/fnagi.2024.1377058. eCollection 2024.
3
"You are my sunshine, my only sunshine": maternal vitamin D status and supplementation in pregnancy and their effect on neonatal and childhood outcomes.“你是我的阳光，我唯一的阳光”：孕期母亲维生素D状态及补充情况及其对新生儿和儿童期结局的影响
Hormones (Athens). 2023 Dec;22(4):547-562. doi: 10.1007/s42000-023-00486-y. Epub 2023 Sep 12.
4
Vitamin D and neurodegenerative diseases.维生素D与神经退行性疾病
Heliyon. 2023 Jan 12;9(1):e12877. doi: 10.1016/j.heliyon.2023.e12877. eCollection 2023 Jan.
5
Vitamin D and Parkinson's Disease.维生素D与帕金森病
Nutrients. 2022 Mar 14;14(6):1220. doi: 10.3390/nu14061220.
6
Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review.基于维生素D的补充剂能否支持大脑健康？一项批判性综述。
Brain Sci. 2020 Sep 22;10(9):660. doi: 10.3390/brainsci10090660.
7
The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.维生素 D 预防胰岛素抵抗及相关疾病的分子机制。
Int J Mol Sci. 2020 Sep 11;21(18):6644. doi: 10.3390/ijms21186644.
8
Analysis of Association between Vitamin D Deficiency and Insulin Resistance.维生素 D 缺乏与胰岛素抵抗的相关性分析。
Nutrients. 2019 Apr 6;11(4):794. doi: 10.3390/nu11040794.
9
Vitamin D and Neurological Diseases: An Endocrine View.维生素 D 与神经疾病：内分泌学视角
Int J Mol Sci. 2017 Nov 21;18(11):2482. doi: 10.3390/ijms18112482.
10
Reduced ability of calcitriol to promote augmented dopamine release in the lesioned striatum of aged rats.骨化三醇促进老年大鼠损伤纹状体中多巴胺释放增加的能力降低。
Neurochem Int. 2017 Sep;108:222-229. doi: 10.1016/j.neuint.2017.04.001. Epub 2017 Apr 5.
本文引用的文献
1
Vitamin d3-induced calcium-binding protein in chick intestinal mucosa.鸡肠黏膜中维生素 D3 诱导的钙结合蛋白。
Science. 1966 May 6;152(3723):791-3. doi: 10.1126/science.152.3723.791.
2
THE PREPARATION OF H3-VITAMINS D2 AND D3--THEIR LOCALIZATION IN THE RAT.H3-维生素D2和D3的制备——它们在大鼠体内的定位
Biochemistry. 1963 Sep-Oct;2:1160-8. doi: 10.1021/bi00905a044.
3
Reduction of brain calcium after consumption of diets deficient in calcium or vitamin D.
J Neurochem. 1981 Feb;36(2):460-6. doi: 10.1111/j.1471-4159.1981.tb01615.x.
4
Brain target sites for 1,25-dihydroxyvitamin D3.1,25-二羟维生素D3的脑靶向位点。
Science. 1982 Mar 12;215(4538):1403-5. doi: 10.1126/science.6977846.
5
Apparent [3H]1,25-dihydroxyvitamin D3 uptake by canine and rodent brain.
Am J Physiol. 1983 Mar;244(3):E266-71. doi: 10.1152/ajpendo.1983.244.3.E266.
6
Localization of salmon calcitonin binding sites in rat brain by autoradiography.
Brain Res. 1983 Aug 8;272(2):373-7. doi: 10.1016/0006-8993(83)90587-5.
7
Vitamin D-dependent rat renal calcium-binding protein: development of a radioimmunoassay, tissue distribution, and immunologic identification.维生素D依赖型大鼠肾钙结合蛋白：放射免疫分析法的建立、组织分布及免疫学鉴定
Endocrinology. 1984 Aug;115(2):640-8. doi: 10.1210/endo-115-2-640.
8
Tests for emotionality in rats and mice: a review.大鼠和小鼠情绪性测试综述
Anim Behav. 1973 May;21(2):205-35. doi: 10.1016/s0003-3472(73)80065-x.
9
[Immunoelectrophoretic quantitation of the brain specific S-100 protein (author's transl)].脑特异性S - 100蛋白的免疫电泳定量分析（作者译）
Acta Neuropathol. 1974;29(3):275-80. doi: 10.1007/BF00685263.
10
Parvalbumin and vitamin D-dependent calcium-binding protein (Mr 28,000): comparison of their localization in the cerebellum of normal and rachitic rats.小白蛋白与维生素D依赖性钙结合蛋白（分子量28,000）：它们在正常及佝偻病大鼠小脑定位的比较
Neurosci Lett. 1985 Aug 16;59(1):97-103. doi: 10.1016/0304-3940(85)90221-6.
Zotero 插件