de Viragh P A, Haglid K G, Celio M R
Institute of Anatomy, University of Zürich, Switzerland.
Proc Natl Acad Sci U S A. 1989 May;86(10):3887-90. doi: 10.1073/pnas.86.10.3887.
The influence of chronic vitamin D3 application on the concentration of the four calcium-binding proteins parvalbumin, the 28-kDa calbindin-D, calmodulin, and S-100 was studied in various brain regions and in the kidney. Young rats were administered daily 20,000 international units of vitamin D3 per kg (body weight) over a period of 4 months. This chronic treatment resulted in a clinically mild hypervitaminosis that did not affect the content of calmodulin, the 28-kDa calbindin-D, and S-100. Also the concentration of parvalbumin in the cerebral cortex, hippocampus, and kidney remained unchanged. On the other hand, parvalbumin was increased about 50% in the caudate putamen of hypervitaminotic animals as compared to controls. Our results indicate that the metabolism of parvalbumin in the caudate putamen can be influenced by variations of the blood level of this steroid hormone.
研究了长期应用维生素D3对不同脑区和肾脏中四种钙结合蛋白（小白蛋白、28 kDa钙结合蛋白-D、钙调蛋白和S-100）浓度的影响。给幼鼠连续4个月每日按每千克（体重）20,000国际单位的剂量给予维生素D3。这种长期治疗导致临床上轻度维生素过多症，但未影响钙调蛋白、28 kDa钙结合蛋白-D和S-100的含量。大脑皮质、海马体和肾脏中小白蛋白的浓度也保持不变。另一方面，与对照组相比，维生素过多症动物的尾状壳核中小白蛋白增加了约50%。我们的结果表明，尾状壳核中小白蛋白的代谢会受到这种甾体激素血液水平变化的影响。
