Wang Yinkang, Shang Xingchen, Zhang Yinchao, Zhang Yu, Shen Wei, Wu Qian, Du Wenyi
Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Wuxi Medical Center of Nanjing Medical University, Wuxi, China.
BMC Public Health. 2025 Jan 14;25(1):157. doi: 10.1186/s12889-025-21392-5.
Several studies have discussed the relationship between cholesterol and gallstones, and high-density lipoprotein cholesterol (HDL-C) as a representative of this has been addressed in various diseases. The metric neutrophil to high-density lipoprotein cholesterol ratio (NHR) derived from HDL-C has attracted much attention. The purpose of this article is to examine the relationship between NHR and gallstones in a population of American adults.
This study investigated the correlation between NHR and gallstone prevalence among US adults using population-based data from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). NHR was derived by dividing the neutrophil count by HDL-C. Data were analyzed using a variety of statistical techniques, such as univariate analysis, multivariate analysis, and subgroup analysis. In addition, a receiver operating characteristic curve (ROC) was used to determine the predictive power of the index for the risk of gallstone prevalence.
The trial enrolled 6,954 subjects, among whom 746 patients were diagnosed with gallstones. By fully adjusted multivariate logistic regression analysis in the Model 3 section observed a significant positive association between NHR and gallstones with an odds ratio (OR) of 1.05 and a 95% confidence interval (CI) of (1.01, 1.10). The restricted cubic curve (RCS) had a P-Nonlinear = 0.481, suggesting that the relationship was a near-linear one. The area under the curve (AUC) of the ROC curve was 0.550, indicating that NHR has a predictive value for the development of gallstones.
This study demonstrated a near-linear correlation between NHR and increased susceptibility to gallstones, and the ROC curve is evidence that NHR has some predictive value for the risk of gallstones, albeit with weak predictive power relative to NPAR (Neutrophil percentage/albumin) and NAR (Neutrophils/albumin). Of course, to confirm these findings, more extensive prospective studies are needed to thoroughly validate the role of NHR in the development of gallstones.
多项研究探讨了胆固醇与胆结石之间的关系，作为其代表的高密度脂蛋白胆固醇（HDL-C）在各种疾病中均有涉及。源自HDL-C的中性粒细胞与高密度脂蛋白胆固醇比值（NHR）受到了广泛关注。本文旨在研究美国成年人群中NHR与胆结石之间的关系。
本研究利用2017 - 2020年美国国家健康与营养检查调查（NHANES）的基于人群的数据，调查美国成年人中NHR与胆结石患病率之间的相关性。NHR通过中性粒细胞计数除以HDL-C得出。数据采用多种统计技术进行分析，如单变量分析、多变量分析和亚组分析。此外，使用受试者工作特征曲线（ROC）来确定该指标对胆结石患病率风险的预测能力。
该试验纳入了6954名受试者，其中746例患者被诊断为胆结石。在模型3部分通过完全调整的多变量逻辑回归分析观察到，NHR与胆结石之间存在显著正相关，优势比（OR）为1.05，95%置信区间（CI）为（1.01，1.10）。受限立方曲线（RCS）的P - 非线性 = 0.481，表明这种关系接近线性。ROC曲线下面积（AUC）为0.550，表明NHR对胆结石的发生具有预测价值。
本研究表明NHR与胆结石易感性增加之间存在接近线性的相关性，ROC曲线证明NHR对胆结石风险具有一定的预测价值，尽管相对于NPAR（中性粒细胞百分比/白蛋白）和NAR（中性粒细胞/白蛋白）其预测能力较弱。当然，为了证实这些发现，需要更广泛的前瞻性研究来彻底验证NHR在胆结石发生中的作用。
