Friberg T R, Rosenstock J, Sanborn G, Vaghefi A, Raskin P
Ophthalmology. 1985 Aug;92(8):1051-8. doi: 10.1016/s0161-6420(85)33903-9.
Thirty-three type l diabetics who used continuous subcutaneous infusion of insulin (CSll) and 24 diabetics on conventional treatment (maximum of two injections per day) were studied prospectively with ophthalmologic examinations, fundus photography, fluorescein angiography, and glycosylated hemoglobin (HbA1) determinations. Both groups were similar with respect to age, duration of diabetes, and length of follow-up. At entry almost all patients had only mild forms of diabetic retinopathy although three CSll patients had early proliferative retinopathy. The CSll groups achieved superior glycemic control throughout the study (mean HbA1 = 7.4% vs. 10.2%). After an average follow-up of more than 30 months, the CSll group showed significantly less progression of diabetic retinopathy as measured by macular aneurysm counts and by modified ETDRS grading. Careful control of glycemia may delay the progression of diabetic retinopathy.
对33名采用胰岛素持续皮下输注（CSII）的1型糖尿病患者和24名接受传统治疗（每天最多两次注射）的糖尿病患者进行了前瞻性研究，包括眼科检查、眼底摄影、荧光素血管造影以及糖化血红蛋白（HbA1）测定。两组在年龄、糖尿病病程和随访时间方面相似。入组时，几乎所有患者仅有轻度糖尿病视网膜病变形式，尽管有3名CSII患者患有早期增殖性视网膜病变。在整个研究过程中，CSII组实现了更好的血糖控制（平均HbA1 = 7.4% 对比10.2%）。经过平均超过30个月的随访，通过黄斑动脉瘤计数和改良的ETDRS分级测量，CSII组的糖尿病视网膜病变进展明显较少。严格控制血糖可能会延缓糖尿病视网膜病变的进展。
