Saleh Salah M, Kadhim Enas F
Al-Wasity Teaching Hospital for Reconstructive and Plastic Surgeries, Baghdad, Iraq.
Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Baghdad, Iraq.
J Taibah Univ Med Sci. 2025 May 8;20(3):255-271. doi: 10.1016/j.jtumed.2025.04.002. eCollection 2025 Jun.
Bone defect repair is a significant challenge in orthopedic medicine.
This study assessed the effectiveness of applying krill oil locally as an osteoinducer in bone healing, and the impact of eucalyptus oil as a stimulant for healing bone defects.
In this study, 48 albino male rats weighing 300-400 g and aged 6-8 months were used, where their environment was carefully monitored, including the amounts of water and food consumed. The experimental test site was the side of the right tibia and the control site was on the left tibia. The treatment was performed on the inner side of the tibia. Bone deficit treatment on the control site involved applying 1 μL of distilled water topically once each day. The experimental treatments were tested in three subgroups: group I received daily local application with 1 μL of krill oil, group II received daily local application with 1 μL of eucalyptus oil, and group III received daily local application with 1 μL of-a combination of krill oil and eucalyptus oil. Six rats were sacrificed at 7 and 14 days after surgery, with 12 rats in each group.
Osteoid tissue development and dramatic increases in the numbers of bone cells were observed after local administration of either krill oil or eucalyptus oil separately, or both substances combined, to a tibia lesion. Notable changes in the area of bone marrow occurred, with increases in the trabecular bone area and gradual decreases in the trabecular bone number.
Combined treatment with krill oil and eucalyptus oil has therapeutic potential for accelerating the mending of bone deformities. Krill and eucalyptus oils can affect osteogenesis and angiogenesis processes.
骨缺损修复是骨科学中的一项重大挑战。
本研究评估局部应用磷虾油作为骨愈合中骨诱导剂的有效性，以及桉叶油作为骨缺损愈合刺激剂的影响。
本研究使用了48只体重300 - 400克、年龄6 - 8个月的白化雄性大鼠，仔细监测它们的生活环境，包括水和食物的摄入量。实验测试部位为右胫骨侧面，对照部位为左胫骨。治疗在胫骨内侧进行。对照部位的骨缺损治疗为每天局部涂抹1微升蒸馏水。实验治疗分为三个亚组进行测试：第一组每天局部应用1微升磷虾油，第二组每天局部应用1微升桉叶油，第三组每天局部应用1微升磷虾油和桉叶油的混合物。术后7天和14天各处死6只大鼠，每组12只。
在胫骨损伤局部单独应用磷虾油或桉叶油，或两者联合应用后，观察到类骨质组织发育以及骨细胞数量显著增加。骨髓面积发生显著变化，小梁骨面积增加，小梁骨数量逐渐减少。
磷虾油和桉叶油联合治疗具有加速骨畸形愈合的治疗潜力。磷虾油和桉叶油可影响骨生成和血管生成过程。
