与低磷脂含量的磷虾油相比，补充高磷脂含量的磷虾油可增加红细胞中 EPA 和 DHA 的总量。
Supplementation of krill oil with high phospholipid content increases sum of EPA and DHA in erythrocytes compared with low phospholipid krill oil.
作者信息
Ramprasath V R, Eyal I, Zchut S, Shafat I, Jones P J H
机构信息
Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB, R3T 2N2, Canada.
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada.
出版信息
Lipids Health Dis. 2015 Nov 4;14:142. doi: 10.1186/s12944-015-0142-y.
BACKGROUND
Bioavailability of krill oil has been suggested to be higher than fish oil as much of the EPA and DHA in krill oil are bound to phospholipids (PL). Hence, PL content in krill oil might play an important role in incorporation of n-3 PUFA into the RBC, conferring properties that render it effective in reducing cardiovascular disease (CVD) risk. The objective of the present trial was to test the effect of different amounts of PL in krill oil on the bioavailability of EPA and DHA, assessed as the rate of increase of n-3 PUFA in plasma and RBC, in healthy volunteers.
METHODS AND DESIGN
In a semi randomized crossover single blind design study, 20 healthy participants consumed various oils consisting of 1.5 g/day of low PL krill oil (LPL), 3 g/day of high PL krill oil (HPL) or 3 g/day of a placebo, corn oil, for 4 weeks each separated by 8 week washout periods. Both LPL and HPL delivered 600 mg of total n-3 PUFA/day along with 600 and 1200 mg/day of PL, respectively.
RESULTS
Changes in plasma EPA, DPA, DHA, total n-3 PUFA, n-6:n-3 ratio and EPA + DHA concentrations between LPL and HPL krill oil supplementations were observed to be similar. Intake of both forms of krill oils increased the RBC level of EPA (p < 0.001) along with reduced n-6 PUFA (LPL: p < 0.001: HPL: p = 0.007) compared to control. HPL consumption increased (p < 0.001) RBC concentrations of EPA, DPA, total and n-3 PUFA compared with LPL. Furthermore, although LPL did not alter RBC n-6:n-3 ratio or the sum of EPA and DHA compared to control, HPL intake decreased (p < 0.001) n-6:n-3 ratio relative to control with elevated (p < 0.001) sum of EPA and DHA compared to control as well as to LPL krill oil consumption. HPL krill oil intake elevated (p < 0.005) plasma total and LDL cholesterol concentrations compared to control, while LPL krill oil did not alter total and LDL cholesterol, relative to control.
CONCLUSIONS
The results indicate that krill oil with higher PL levels could lead to enhanced bioavailability of n-3 PUFA compared to krill oil with lower PL levels.
TRIAL REGISTRATION
Clinicaltrials.gov# NCT01323036.
背景
有研究表明磷虾油的生物利用度高于鱼油，因为磷虾油中的大部分二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）与磷脂（PL）结合。因此，磷虾油中的PL含量可能在n-3多不饱和脂肪酸（PUFA）掺入红细胞的过程中发挥重要作用，赋予其降低心血管疾病（CVD）风险的功效。本试验的目的是测试磷虾油中不同含量的PL对健康志愿者体内EPA和DHA生物利用度的影响，以血浆和红细胞中n-3 PUFA的增加速率来评估。
方法与设计
在一项半随机交叉单盲设计研究中，20名健康参与者分别食用不同的油，包括每天1.5克低PL磷虾油（LPL）、每天3克高PL磷虾油（HPL）或每天3克安慰剂玉米油，每种持续4周，期间间隔8周的洗脱期。LPL和HPL每天均提供600毫克的总n-3 PUFA，同时分别含有600毫克和1200毫克的PL。
结果
观察到LPL和HPL磷虾油补充期间血浆中EPA、二十二碳五烯酸（DPA）、DHA、总n-3 PUFA、n-6:n-3比值以及EPA + DHA浓度的变化相似。与对照组相比，两种形式的磷虾油摄入均使红细胞中的EPA水平升高（p < 0.001），同时n-6 PUFA降低（LPL：p < 0.001；HPL：p = 0.007）。与LPL相比，食用HPL使红细胞中EPA、DPA、总n-3 PUFA浓度升高（p < 0.001）。此外，虽然与对照组相比LPL未改变红细胞n-6:n-3比值或EPA与DHA的总和，但与对照组相比，HPL的摄入降低了n-6:n-3比值（p < 0.001），且与对照组及LPL磷虾油摄入相比，EPA与DHA的总和升高（p < 0.001）。与对照组相比，摄入HPL磷虾油使血浆总胆固醇和低密度脂蛋白胆固醇浓度升高（p < 0.005），而LPL磷虾油与对照组相比未改变总胆固醇和低密度脂蛋白胆固醇水平。
结论
结果表明，与低PL水平的磷虾油相比，高PL水平的磷虾油可提高n-3 PUFA的生物利用度。
试验注册
Clinicaltrials.gov# NCT01323036。
Zotero 插件