Zhai Tingting, Wei Yuhan, Wang Lihua, Li Jiang, Fan Chunhai
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Institute of Materiobiology, Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China.
Fundam Res. 2022 Oct 31;3(4):520-524. doi: 10.1016/j.fmre.2022.10.011. eCollection 2023 Jul.
Airborne diseases including SARS, bird flu, and the ongoing Coronavirus Disease 2019 (COVID-19) have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale screening. Here, we briefly summarize the state-of-the-art methods for the detection of infectious pathogens and discuss key challenges. We highlight the trend for next-generation technologies benefiting from multidisciplinary advances in microfabrication, nanotechnology and synthetic biology, which allow sensitive, rapid yet inexpensive pathogen assays with portable intelligent device.
包括非典、禽流感以及当前的2019冠状病毒病（COVID-19）在内的空气传播疾病，激发了对开发能够进行早期诊断和大规模筛查的新型生物检测方法的需求。在此，我们简要总结了检测传染性病原体的最新方法，并讨论了关键挑战。我们强调了受益于微纳加工、纳米技术和合成生物学多学科进展的下一代技术的发展趋势，这些进展使便携式智能设备能够实现灵敏、快速且低成本的病原体检测。
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