Influences of obstacle factors on the transmission trends of respiratory infectious diseases in indoor public places.

Public facilities are important transmission places for respiratory infectious diseases (e.g., COVID-19), due to the frequent crowd interactions inside. Usually, changes of obstacle factors can affect the movements of human crowds and result in different epidemic transmissions among individuals. However, most related studies only focus on the specific scenarios, but the common rules are usually ignored for the impacts of obstacles' spatial elements on epidemic transmission. To tackle these problems, this study aims to evaluate the impacts of three spatial factors of obstacles (i.e., size, quantity, and placement) on infection spreading trends in two-dimension, which can provide scientific and concise spatial design guidelines for indoor public places. , we used the obstacle area proportion as the indicator of the size factor, gave the mathematical expression of the quantity factor, and proposed the walkable-space distribution indicator to represent the placement factor by introducing the Space Syntax. , two spreading epidemic indicators (i.e., daily new cases and people's average exposure risk) were estimated based on the fundamental model named exposure risk with the virion-laden particles, which accurately forecasted the disease spreading between individuals. , 120 indoor scenarios were built and simulated, based on which the value of independent and dependent variables can be measured. Besides, structural equation modeling was employed to examine the effects of obstacle factors on epidemic transmissions. , three obstacle-related guidelines were provided for policymakers to mitigate the disease spreading: minimizing the size of obstacles, dividing the obstacle into more sub-ones, and placing obstacles evenly distributed in space.