多靶点蛋白簇的颜色映射
Color mapping of multitarget protein clusters.
作者信息
Gunasekara Hirushi, Hu Ying S
机构信息
Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL 60607, USA.
Department of Chemistry, College of Liberal Arts and Sciences, University of Illinois Chicago, Chicago, IL 60607, USA; Department of Biomedical Engineering, Colleges of Engineering and Medicine, University of Illinois Chicago, Chicago, IL 60607, USA; University of Illinois Cancer Center, Chicago, IL 60612, USA.
出版信息
Structure. 2025 Jun 5;33(6):991-993. doi: 10.1016/j.str.2025.05.004.
Visualizing subcellular distributions of proteins and assessing their colocalization patterns are central to understanding the organization and interactions of molecular assemblies. In this issue of Structure, Kiuchi et al. introduce protein cluster coloring to map complex association patterns among eight endogenous proteins at the periphery of the clathrin-coated structure, revealing their multilayered complex associations upon epidermal growth factor stimulation.
可视化蛋白质的亚细胞分布并评估它们的共定位模式对于理解分子组装体的组织和相互作用至关重要。在本期《结构》杂志中，木内等人引入了蛋白质簇着色法，以绘制网格蛋白包被结构周边八种内源性蛋白质之间的复杂关联模式，揭示了它们在表皮生长因子刺激下的多层复杂关联。
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