Peiker G, Schröder S, Müller B
Pharmazie. 1985 Jul;40(7):480-1.
In this paper pharmacokinetic data of ampicillin in 9 pregnant women with H-gestosis are compared with those from 8 healthy pregnant women in the last trimenon. 5 g Ampicillin were given as an i.v. bolus-injection. Ampicillin was determined in serum and urine by a polarographic method. Important kinetic data, such as concentration in serum, distribution into the peripheral compartment and t1/2 beta do not differ. The non-significantly changed central distribution volume (V1) as well as the reduced renal excretion in combination with normal serum creatinin values have to be considered in connection with the general constriction of blood vessels in pregnant women with H-gestosis. From the kinetic data one cannot derive any necessity for changing the mode of application or the dose of ampicillin in pregnant women with H-gestosis.
本文将9例患妊娠高血压综合征孕妇的氨苄西林药代动力学数据与8例孕晚期健康孕妇的相应数据进行了比较。静脉推注5g氨苄西林。采用极谱法测定血清和尿液中的氨苄西林。血清浓度、外周室分布及β半衰期等重要动力学数据无差异。妊娠高血压综合征孕妇出现全身血管收缩，应考虑其中心分布容积（V1）变化不显著以及肾排泄减少但血清肌酐值正常的情况。从动力学数据来看，没有必要改变妊娠高血压综合征孕妇使用氨苄西林的给药方式或剂量。
