[The pharmacokinetics of ampicillin in pregnant women with H-gestosis in the last trimester of pregnancy].

In this paper pharmacokinetic data of ampicillin in 9 pregnant women with H-gestosis are compared with those from 8 healthy pregnant women in the last trimenon. 5 g Ampicillin were given as an i.v. bolus-injection. Ampicillin was determined in serum and urine by a polarographic method. Important kinetic data, such as concentration in serum, distribution into the peripheral compartment and t1/2 beta do not differ. The non-significantly changed central distribution volume (V1) as well as the reduced renal excretion in combination with normal serum creatinin values have to be considered in connection with the general constriction of blood vessels in pregnant women with H-gestosis. From the kinetic data one cannot derive any necessity for changing the mode of application or the dose of ampicillin in pregnant women with H-gestosis.