Whitehead W E, Engel B T, Schuster M M
Dig Dis Sci. 1980 Jun;25(6):404-13. doi: 10.1007/BF01395503.
Patients with different irritable bowel symptoms and normal subjects were compared to determine whether subtypes of irritable bowel syndrome (IBS) could be distinguished on the basis of colonic motility or psychological test scores. A provocative test involving stepwise distension of the rectosigmoid area revealed two types of colonic motility. Slow contractions having durations of at least 15 sec and occurring at irregular intervals were more frequent in IBS patients than in normals but did not differentiate constipation from diarrhea. Fast contractions having durations of less than 15 sec and occurring in runs at frequencies of 6-9 cpm were more frequent in patients with diarrhea than in normals or constipated IBS patients. Constipated patients showed no more fast contractions than normals. Severity of bowel symptoms was correlated with the overall amount of motility (motility index) in patients with diarrhea but not in patients with constipation. Patients with IBS showed significantly elevated levels on the following psychological traits: anxiety, interpersonal sensitivity, depression, hostility, and somatization of affect. However, there were no significant trait differences between patients with diarrhea and those with constipation. Also, there was no correlationbetween amount of psychopathology and either colonic motility or severity of symptoms in the whole group of IBS patients.
对患有不同肠易激症状的患者和正常受试者进行比较，以确定是否可以根据结肠运动或心理测试分数来区分肠易激综合征（IBS）的亚型。一项涉及直肠乙状结肠区域逐步扩张的激发试验揭示了两种结肠运动类型。持续时间至少15秒且间隔不规则的缓慢收缩在IBS患者中比在正常人中更常见，但不能区分便秘型和腹泻型。持续时间少于15秒且以每分钟6 - 9次的频率连续出现的快速收缩在腹泻患者中比在正常人和便秘型IBS患者中更常见。便秘患者的快速收缩并不比正常人多。腹泻患者的肠道症状严重程度与总体运动总量（运动指数）相关，而便秘患者则不然。IBS患者在以下心理特质上的水平显著升高：焦虑、人际敏感性、抑郁、敌意和情感躯体化。然而，腹泻患者和便秘患者之间在特质上没有显著差异。此外，在整个IBS患者组中，精神病理学程度与结肠运动或症状严重程度之间没有相关性。
