Shertukde Shruti P, Padmanabha Ramya, Chung Stephanie T, Gaudichon Claire, Jones Kerry S, Kelly Paul, Krebs Nancy F, Kurpad Anura, Lamers Yvonne, Lopez-Teros Veronica, Melse-Boonstra Alida, Pereira Fatima C, Prado Carla M, Roberts Susan B, Shepherd John, Winichagoon Pattanee, Wells Jonathan C K, Loechl Cornelia U, Hoffman Daniel J
Nutrition and Health-Related Environmental Studies Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
Nutrition and Health-Related Environmental Studies Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria; Division of Nutrition, St. John's Research Institute, Bengaluru, India.
Am J Clin Nutr. 2025 Aug;122(2):646-655. doi: 10.1016/j.ajcnut.2025.06.003. Epub 2025 Jun 6.
Malnutrition in all its forms-including undernutrition, micronutrient deficiencies, and overnutrition-continues to rise globally, driven by complex structural and biological factors that contribute to an increased risk of noncommunicable diseases (NCDs). Addressing this multifaceted challenge requires precise assessment tools. To advance this effort, the International Atomic Energy Agency held a technical meeting of global experts to explore how nuclear techniques, specifically stable isotope tracers and imaging methods, and emerging technologies can enhance nutrition assessments to better address malnutrition. On the basis of the meeting's discussions, this report highlights the application of nuclear techniques to improve the measurement of body composition across life stages and disease states, assess nutrient bioavailability more holistically, elucidate nutrient flux under conditions of malnutrition, trace metabolic processes linked to NCDs, and refine nutrient requirements to better reflect diverse populations. The integration of nuclear techniques with emerging tools such as artificial intelligence and model-based compartmental analysis was emphasized as a key strategy to enhance their utility. This report also highlights the important role of nuclear techniques in addressing malnutrition and calls for interdisciplinary collaboration and reduced research silos to fully leverage these techniques to combat this condition more effectively.
各种形式的营养不良,包括营养不足、微量营养素缺乏和营养过剩,在全球范围内持续增加,其驱动因素是复杂的结构和生物因素,这些因素会增加患非传染性疾病的风险。应对这一多方面的挑战需要精确的评估工具。为推动这项工作,国际原子能机构召开了一次全球专家技术会议,探讨核技术,特别是稳定同位素示踪剂和成像方法,以及新兴技术如何能够加强营养评估,以更好地应对营养不良问题。基于会议讨论,本报告重点介绍了核技术在以下方面的应用:改善对不同生命阶段和疾病状态下身体成分的测量;更全面地评估营养素生物利用度;阐明营养不良状况下的营养通量;追踪与非传染性疾病相关的代谢过程;以及完善营养需求,以更好地反映不同人群的情况。强调将核技术与人工智能和基于模型的隔室分析等新兴工具相结合是提高其效用的关键策略。本报告还强调了核技术在应对营养不良方面的重要作用,并呼吁开展跨学科合作,减少研究壁垒,以充分利用这些技术更有效地对抗这种状况。