Dimitriadis Nikos, Notara Venetia, Kokkou Stamatia, Kotoulas Petros, Kokkinidou Lydia, Tsina Elpida, Theochari Christina, Kogias Yannis, Papanagnou George, Zombolos Spyros, Stravopodis Petros, Mantas Yannis, Lagiou Areti, Arnaoutis Giannis, Tambalis Konstantinos D, Pitsavos Christos, Panagiotakos Demosthenes
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece.
Am J Lifestyle Med. 2025 Jun 4:15598276251347894. doi: 10.1177/15598276251347894.
The aim of the present study is to investigate the association between 20-year trajectories of physical activity status and cardiovascular disease (CVD) incidence, among Acute Coronary Syndrome (ACS) patients. GREECS study is a multi-centered prospective study. Almost all (n = 2172; mean age 62 ± 11 years; 1649 (76%) males) consecutive patients who were hospitalized in the cardiology clinics or the emergency cardiology departments were entered in the study. Four physical activity trajectories were formed regarding the 20-year tracking (from 2004 to 2024), of their physical activity levels (i.e., always inactive or active, turned from inactive/active). Of the 1913 ACS patients who participated in the 20-year follow-up, 51% were consistently inactive, 31% changed from physically active to inactive, 11% from inactive to active, and 7% were consistently active. During the 20-year follow-up 67% of ACS patients experienced a new CVD event. Consistently active patients had 45% lower risk for a recurrent CVD event during the 20-year follow-up period (95% CI, 12% to 64%), as compared to consistently inactive. Sustained engagement in physical activity is associated with a reduced risk of recurrent CVD events among ACS patients. These findings underscore the importance of promoting and sustaining physical activity as a key component of tertiary CVD prevention.
本研究旨在调查急性冠状动脉综合征（ACS）患者身体活动状况的20年轨迹与心血管疾病（CVD）发病率之间的关联。GREECS研究是一项多中心前瞻性研究。几乎所有（n = 2172；平均年龄62±11岁；1649名（76%）男性）在心脏病诊所或心脏病急诊科住院的连续患者都纳入了该研究。根据其身体活动水平的20年追踪情况（从2004年到2024年）形成了四种身体活动轨迹（即一直不活动或活动、从不活动/活动转变）。在参与20年随访的1913名ACS患者中，51%一直不活动，31%从身体活动转变为不活动，11%从不活动转变为活动，7%一直活动。在20年随访期间，67%的ACS患者发生了新的CVD事件。与一直不活动的患者相比，一直活动的患者在20年随访期间复发性CVD事件的风险降低了45%（95%CI，12%至64%）。持续进行身体活动与ACS患者复发性CVD事件风险降低相关。这些发现强调了促进和维持身体活动作为三级CVD预防关键组成部分的重要性。
