Chen Siru, Li Tiange, Zhao Peijun, Liang Puye, Huang Xianqing, Song Lianjun, Wang Tianlin
College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China.
Curr Res Food Sci. 2025 May 14;10:101081. doi: 10.1016/j.crfs.2025.101081. eCollection 2025.
Obesity is closely associated with cardiovascular disease, type 2 diabetes, and other long-term health complications. The indication of browning in white adipose tissue (WAT) has emerged as a promising strategy to combat obesity. This study investigates the effect of stachyose (STA) on WAT browning in mice fed a high-fat diet (HFD). Our findings demonstrated that STA significantly inhibited body weight gain, improved glucose tolerance, and reduced serum levels of inflammatory biomarkers in HFD-induced overweight mice. STA administration promoted WAT browning and enhanced brown adipose tissue activity, as evidenced by increased protein levels of uncoupling protein 1 and other browning markers. Additionally, STA treatment modulated gut microbiota composition, regulated hepatic bile acids levels, and maintained intestinal barrier integrity. These results suggest that STA alleviates obesity by inducing WAT browning and modulating gut microbiota.
肥胖与心血管疾病、2型糖尿病及其他长期健康并发症密切相关。白色脂肪组织（WAT）褐变现象的出现，成为对抗肥胖的一种有前景的策略。本研究调查了水苏糖（STA）对高脂饮食（HFD）喂养小鼠WAT褐变的影响。我们的研究结果表明，STA显著抑制了HFD诱导的超重小鼠的体重增加，改善了葡萄糖耐量，并降低了炎症生物标志物的血清水平。STA给药促进了WAT褐变并增强了棕色脂肪组织活性，解偶联蛋白1和其他褐变标志物的蛋白质水平增加证明了这一点。此外，STA治疗调节了肠道微生物群组成，调节了肝脏胆汁酸水平，并维持了肠道屏障完整性。这些结果表明，STA通过诱导WAT褐变和调节肠道微生物群来减轻肥胖。
