College of Chemical Engineering, Huaqiao University, Jimei Road, Jimei District, Xiamen 361021, Fujian, China; Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Jimei Road, Jimei District, Xiamen 361021, Fujian, China.
College of Chemical Engineering, Huaqiao University, Jimei Road, Jimei District, Xiamen 361021, Fujian, China.
Carbohydr Polym. 2022 Nov 15;296:119903. doi: 10.1016/j.carbpol.2022.119903. Epub 2022 Jul 22.
Obesity is nowadays a serious public health issue. Neoagarotetraose (NA4) is a marine oligosaccharide produced by the enzymatic hydrolysis of agar by β-agarase. The present study is aimed to determine the effect of NA4 on high-fat diet (HFD)-induced obesity in mice and uncover the regulating role of gut microbiota and microbial metabolites. The results showed that the intervention of NA4 significantly reduced the body weight gain, insulin resistance, hepatic adipose accumulation, serum lipid levels, oxidative damages, and inflammation responses in HFD-induced obese mice. NA4 also promoted lipolysis and browning of white adipose tissue, inhibit lipogenesis, and protect the integrity of gut barrier. Moreover, NA4 restructured the altered gut microbiota and enhanced the content of short-chain fatty acids (SCFAs) in the feces with compared with the HFD group. Cumulatively, these findings suggest that NA4 can relieve obesity by stimulating white adipose tissue browning, regulating intestinal flora, and promoting microbial metabolism.
如今，肥胖是一个严重的公共卫生问题。Neoagarotetraose (NA4) 是一种海洋低聚糖，由 β-agarase 对琼脂进行酶解产生。本研究旨在确定 NA4 对高脂肪饮食（HFD）诱导肥胖小鼠的影响，并揭示肠道微生物群和微生物代谢物的调节作用。结果表明，NA4 的干预显著降低了 HFD 诱导肥胖小鼠的体重增加、胰岛素抵抗、肝脂肪堆积、血清脂质水平、氧化损伤和炎症反应。NA4 还促进了白色脂肪组织的脂肪分解和棕色化，抑制了脂肪生成，并保护了肠道屏障的完整性。此外，与 HFD 组相比，NA4 还改变了肠道微生物群，并增加了粪便中短链脂肪酸（SCFAs）的含量。综上所述，这些发现表明，NA4 通过刺激白色脂肪组织棕色化、调节肠道菌群和促进微生物代谢来缓解肥胖。
