Achuta Kesava Manikanta, Vedantam Venkata, Kommineni Sai Karthik, Vedantam Neethu, Venisha Kyasa S
Internal Medicine, Garden City Hospital, Michigan State University, Dearborn Heights, USA.
Internal Medicine, East Tennessee State University Quillen College of Medicine, Johnson City, USA.
Cureus. 2025 May 8;17(5):e83713. doi: 10.7759/cureus.83713. eCollection 2025 May.
Bradycardia, renal failure, atrioventricular (AV) nodal blocker usage, shock, and hyperkalemia are the hallmarks of BRASH syndrome, a complex medical emergency. Despite having a high mortality rate, BRASH syndrome is underdiagnosed and frequently develops from the combined effects of renal failure and drug toxicity. Here, we present the case of an 86-year-old woman with end-stage renal disease (ESRD) who developed BRASH syndrome due to missed dialysis sessions, exacerbated by low-dose beta-blocker therapy. This case emphasizes how crucial it is to identify BRASH syndrome early, treat it quickly, and address its untoward events to avoid fatalities.
心动过缓、肾衰竭、房室（AV）结阻滞剂的使用、休克和高钾血症是BRASH综合征的特征，这是一种复杂的内科急症。尽管BRASH综合征死亡率很高，但它常未被诊断出来，且常由肾衰竭和药物毒性的综合作用引发。在此，我们报告一例86岁终末期肾病（ESRD）女性病例，该患者因错过透析疗程而发生BRASH综合征，低剂量β受体阻滞剂治疗使其病情加重。该病例强调了早期识别BRASH综合征、迅速治疗并应对其不良事件以避免死亡的重要性。
