Kjaeldgaard A, Anker C, Larsson B
Res Exp Med (Berl). 1985;185(4):277-81. doi: 10.1007/BF01851952.
The influence of different intrauterine devices (IUDs) on the uterine fibrinolysis has been extensively studied in rodents with two uterine horns. In this experimental model an IUD is inserted into one horn by a surgical procedure including laparotomy and uterotomy. The effect of these two surgical steps on the fibrinolysis in the endometrium determined according to Todd's histochemical fibrin slide technique was studied in the present series comprising 26 rats. The fibrinolytic activity (FA) in the rat uterus was independent of the biopsy site in the uterine horns. However, significant depression of endometrial fibrinolysis was demonstrated 2 weeks after laparotomy, whereas no effect of a tiny incision in the uterine wall was recorded. In conclusion, a sham operation of the control horn in rodent studies on the fibrinolytic effect of IUDs according to this experimental model is not necessary.
不同宫内节育器（IUD）对具有两个子宫角的啮齿动物子宫纤维蛋白溶解的影响已得到广泛研究。在这个实验模型中，通过包括剖腹术和子宫切开术的外科手术将一枚宫内节育器插入一个子宫角。在本系列的26只大鼠中，研究了这两个手术步骤对根据托德组织化学纤维蛋白玻片技术测定的子宫内膜纤维蛋白溶解的影响。大鼠子宫中的纤维蛋白溶解活性（FA）与子宫角中的活检部位无关。然而，剖腹术后2周子宫内膜纤维蛋白溶解明显降低，而子宫壁微小切口未记录到影响。总之，在根据该实验模型进行的关于宫内节育器纤维蛋白溶解作用的啮齿动物研究中，对照子宫角的假手术没有必要。
