Kjaeldgaard A
Res Exp Med (Berl). 1986;186(1):15-9. doi: 10.1007/BF01851829.
The validity of a frequently used experimental model for evaluating the effect of different intrauterine devices (IUDs) on uterine fibrinolysis in rodents was investigated in 42 rats. In this model, an IUD is inserted into one horn by a surgical procedure including laparotomy and uterotomy, while the other empty horn is used as a control. In the present investigation, the fibrinolytic activity in different parts of the IUD-containing and control horn was related to the localization of the IUD. The fibrinolytic activity as determined according to Todd's histochemical fibrin slide method was significantly increased in the endometrium in direct contact with the IUD as well as in the uterine segment opposite to the IUD. The enhancement of fibrinolysis in the opposite segment of the control horn was independent of the localization of the IUD, suggesting that neurogenic mechanisms may underlie the stimulation of uterine fibrinolysis in the empty horn. It was concluded that this experimental model is less suitable for evaluating the effect of IUDs on uterine fibrinolysis, since the presence of an IUD in one uterine horn also influences the fibrinolytic activity of the other horn.
在42只大鼠中研究了一种常用的实验模型评估不同宫内节育器（IUD）对啮齿动物子宫纤维蛋白溶解作用的有效性。在该模型中，通过包括剖腹术和子宫切开术的外科手术将一个IUD插入一侧子宫角，而另一侧空的子宫角用作对照。在本研究中，含IUD子宫角和对照子宫角不同部位的纤维蛋白溶解活性与IUD的位置有关。根据托德组织化学纤维蛋白玻片法测定，与IUD直接接触的子宫内膜以及IUD相对的子宫段中的纤维蛋白溶解活性显著增加。对照子宫角相对段中纤维蛋白溶解的增强与IUD的位置无关，这表明神经源性机制可能是刺激空子宫角子宫纤维蛋白溶解的基础。得出的结论是，该实验模型不太适合评估IUD对子宫纤维蛋白溶解的作用，因为一个子宫角中IUD的存在也会影响另一个子宫角的纤维蛋白溶解活性。
