关于体育活动干预及其组成部分对自闭症谱系障碍患者重复刻板行为影响的系统评价和随机对照试验的荟萃分析。
Systematic review and randomized controlled trial meta-analysis of the effects of physical activity interventions and their components on repetitive stereotyped behaviors in patients with autism spectrum disorder.
作者信息
Yang Juanjuan, Li Ruxin
机构信息
School of Physical Education and Health, Shanghai Lixin University of Accounting and Finance, Shanghai, China.
Sports Institute, Hunan University of Finance and Economics, Changsha, Hunan, China.
出版信息
Front Psychol. 2025 May 23;16:1579345. doi: 10.3389/fpsyg.2025.1579345. eCollection 2025.
OBJECTIVE
To systematically evaluate the effect of exercise intervention and its components on repetitive stereotyped behaviors in patients with autism spectrum disorder (ASD).
METHODS
A computer-based search was conducted in PubMed, Web of Science, The Cochrane Library, and EMbase databases for randomized controlled trials (RCTs) related to exercise interventions for repetitive stereotyped behaviors in patients with ASD. The search covered all available data from the inception of each database until January 2025. Meta-analysis was performed using RevMan 5.4 software, methodological quality was assessed using the ROB scale, and publication bias was evaluated using Stata 17.0 software.
RESULTS
A total of 20 RCTs were included, comprising 671 patients with ASD. The meta-analysis results showed that exercise intervention had a positive effect on repetitive stereotyped behaviors in patients with ASD (SMD = -0.37, 95% CI: -0.52, -0.21, < 0.05). Subgroup analysis results indicated that ball sports (SMD = -0.72, 95% CI: -1.09, -0.36, < 0.001), longer duration (SMD = -0.55, 95% CI: -0.98, -0.12, < 0.05), moderate to high frequency (SMD = -0.74, 95% CI: -1.05, -0.44, < 0.001), longer time (SMD = -0.84, 95% CI: -1.26, -0.42, < 0.001), and group participation (SMD = -0.48, 95% CI: -0.74, -0.21, p < 0.001) might show optimal dose-response relationships.
CONCLUSION
Exercise intervention can effectively improve repetitive stereotyped behaviors in patients with ASD. The components of exercise intervention show a dose-response effect, with the best results likely occurring from ball sports, medium to long durations, moderate to high frequency, longer time, and group participation.
SYSTEMATIC REVIEW REGISTRATION
The protocol for this meta-analysis has been registered in INPLASY, with the registration number INPLASY202520074.
目的
系统评价运动干预及其组成部分对自闭症谱系障碍（ASD）患者重复刻板行为的影响。
方法
在PubMed、Web of Science、Cochrane图书馆和EMbase数据库中进行基于计算机的检索，以查找与ASD患者重复刻板行为的运动干预相关的随机对照试验（RCT）。检索涵盖了每个数据库自创建以来直至2025年1月的所有可用数据。使用RevMan 5.4软件进行荟萃分析，使用ROB量表评估方法学质量，并使用Stata 17.0软件评估发表偏倚。
结果
共纳入20项RCT，包括671例ASD患者。荟萃分析结果显示，运动干预对ASD患者的重复刻板行为有积极影响（标准化均数差[SMD]=-0.37，95%置信区间：-0.52，-0.21，P<0.05）。亚组分析结果表明，球类运动（SMD=-0.72，95%置信区间：-1.09，-0.36，P<0.001）、持续时间较长（SMD=-0.55，95%置信区间：-0.98，-0.12，P<0.05）、中高频（SMD=-0.74，95%置信区间：-1.05，-0.44，P<0.001）、时间较长（SMD=-0.84，95%置信区间：-1.26，-0.42，P<0.001）和团体参与（SMD=-0.48，95%置信区间：-0.74，-0.21，P<0.001）可能显示出最佳的剂量反应关系。
结论
运动干预可有效改善ASD患者的重复刻板行为。运动干预的组成部分显示出剂量反应效应，球类运动、中长时间、中高频、较长时间和团体参与可能产生最佳效果。
系统评价注册
本荟萃分析的方案已在INPLASY注册，注册号为INPLASY202520074。
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