Osborne Natasha D, Harrison Julia M, Tang David, Joukhadar Nadim G, Bezuhly Michael
Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.
Division of Plastic Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
Plast Surg (Oakv). 2025 Jun 5:22925503251344305. doi: 10.1177/22925503251344305.
Dupuytren disease (DD) is a fibroproliferative disorder characterized by excess collagen deposition in the digitopalmar fascia resulting in disabling flexion contractures. The angiotensin II type 1 receptor (AT1R) pathway has previously been shown to be upregulated in a variety of other fibrotic disorders. We explored the potential association between DD and activating autoantibodies (AAb) against the profibrotic AT1R or counterregulatory antifibrotic angiotensin II type 2 receptor (AT2R). Patients with DD and controls were recruited from a single hand clinic. Demographic and clinical data and total flexion deformity angle of each digit were recorded. Serum levels of AT1R-AAb and AT2R-AAb were measured by enzyme-linked immunosorbent assay. No differences were noted in serum AT1R-AAb levels between control and DD patients. In women with DD, circulating AT2R-AAb were significantly lower than in control women (7.61 ± 3.0 U/mL vs 13.5 ± 3.1 U/mL, respectively). AT2R-AAb observed values tended to be lower in women with higher Tubiana severity scores. In contrast, AT2R-AAb levels were not different between control or DD male subjects. These early findings suggest angiotensin II signaling differences may contribute to sex differences in DD and that an AT2R agonist may be particularly beneficial in treating women with DD.
Diagnostic, Level II.
杜普伊特伦挛缩病（DD）是一种纤维增生性疾病，其特征是指掌筋膜中胶原蛋白过度沉积，导致致残性屈曲挛缩。先前已表明，1型血管紧张素II受体（AT1R）通路在多种其他纤维化疾病中上调。我们探讨了DD与针对促纤维化AT1R或反调节抗纤维化2型血管紧张素II受体（AT2R）的激活自身抗体（AAb）之间的潜在关联。DD患者和对照组均从一家手部诊所招募。记录人口统计学和临床数据以及每个手指的总屈曲畸形角度。采用酶联免疫吸附测定法测量血清AT1R-AAb和AT2R-AAb水平。对照组和DD患者的血清AT1R-AAb水平无差异。在患有DD的女性中，循环AT2R-AAb显著低于对照女性（分别为7.61±3.0 U/mL和13.5±3.1 U/mL）。在Tubiana严重程度评分较高的女性中，观察到的AT2R-AAb值往往较低。相比之下，对照组或DD男性受试者之间的AT2R-AAb水平没有差异。这些早期发现表明，血管紧张素II信号差异可能导致DD的性别差异，并且AT2R激动剂可能对治疗患有DD的女性特别有益。
诊断性，II级。
