Colantonio Mark A, Sblendorio Danielle, Hart Elizabeth, Wiley Joshua
Department of Medicine, West Virginia University, Morgantown, WV, USA.
Department of Neurology, West Virginia University, Morgantown, WV, USA.
Radiol Case Rep. 2025 May 8;20(7):3628-3631. doi: 10.1016/j.radcr.2025.04.048. eCollection 2025 Jul.
Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) is a novel, demyelinating disease presenting with optic neuritis, along with other central nervous pathologies. First implicated in 2007, it remains a rare disease, with a prevalence of roughly 1.3 per 1 million adults. We present a case of MOGAD in a young female presenting to our rural healthcare facility with endorsements of eye pain and blurred vision. Imaging revealed findings consistent with optic neuritis, as well as hyperintensities of her cerebrum and cervical spine. Distinguishing radiographic features from other neurological pathologies, including conus medullaris enhancement, were not present, highlighting the importance of considering the clinical picture as a whole. We aim to bring awareness to this rare disease, especially to those practitioners localized to a rural environment.
髓鞘少突胶质细胞糖蛋白抗体病（MOGAD）是一种新型脱髓鞘疾病，表现为视神经炎以及其他中枢神经病变。该病于2007年首次被发现，仍然是一种罕见疾病，每100万成年人中约有1.3例患病。我们报告了一例年轻女性MOGAD病例，该患者因眼痛和视力模糊前来我们的乡村医疗机构就诊。影像学检查发现与视神经炎相符的表现，以及其大脑和颈椎的高信号。未发现与其他神经病变（包括圆锥马尾强化）相区别的影像学特征，这凸显了综合考虑临床情况的重要性。我们旨在提高对这种罕见疾病的认识，尤其是对那些身处乡村环境的从业者。
