Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Berlin School of Mind and Brain, Berlin Institute of Health at Charité - Universitätsmedizin Berlin and, Humboldt-Universität zu Berlin, Berlin, Germany.
Clin Exp Immunol. 2021 Dec;206(3):266-281. doi: 10.1111/cei.13641. Epub 2021 Jul 18.
Myelin oligodendrocyte glycoprotein antibody-associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody-associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In-vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord and optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and neuroimaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how image analysis methods have led to recent insights for consideration in future studies.
髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）在儿童和成人中均较为罕见，最近有研究提示其为一种不同于水通道蛋白 4 自身抗体相关视神经脊髓炎谱系疾病和经典多发性硬化的自身免疫性神经炎症性疾病组。MOGAD 患者中枢神经系统的体内影像学检查在评估脑、脊髓和视神经磁共振成像以及使用光学相干断层扫描进行视网膜成像时显示出一些独特特征。在这篇综述中，我们讨论了儿科和成人 MOGAD 的关键临床和神经影像学特征。我们描述了这些影像学技术如何用于研究这组疾病，并讨论了图像分析方法如何为未来研究提供新的思路。
