Zhang Lei, Wang Ting, Zhou Shan, Li Shengpeng, Mo Ting, Wu Shuanghua
The Friendship Hospital of Yili Kazakh Autonomous Prefecture, Yining, China.
Department of Rehabilitation Medicine, Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University, Zhuzhou, China.
Front Public Health. 2025 May 23;13:1580863. doi: 10.3389/fpubh.2025.1580863. eCollection 2025.
The strategy for eliminating viral hepatitis is at a critical juncture, necessitating an updated assessment of global incidence trends.
Data on the incidence of four types of acute viral hepatitis (AVH), namely, acute hepatitis A (AHA), acute hepatitis B (AHB), acute hepatitis C (AHC), and acute hepatitis E (AHE), were sourced from the Global Burden of Disease (GBD) Study 2021. The annual percentage change is utilized to elucidate temporal trends, whereas health inequalities and frontier analysis serve to evaluate global health equity and quantify disparities in burden among countries.
In 2021, the estimated global incidence for AVH was as follows: AHA (160.86 million), AHB (63.53 million), AHE (19.37 million), and AHC (7.01 million). From 2000 to 2021, the age-standardized incidence rates (ASIR) for four types of AVH demonstrated a declining trend, with AHB showing the most significant decrease. It is anticipated that the incidence rates for AHA, AHB, and AHC will continue to decline over the next 15 years; however, the incidence rate of AHE is projected to increase. In 2021, the incidence of AVH displayed a significant negative correlation with the Socio-Demographic Index (SDI), but health disparities between countries have diminished. Countries with the highest potential for elimination of AHB are primarily situated in low and low-middle SDI regions, whereas those for AHA are concentrated in high and high-middle SDI regions. Furthermore, countries with the largest disparities in AHC and AHE were dispersed.
Although global incidence of AVH is decreasing, it remains a serious public health challenge. Reducing health disparities is crucial for the elimination of viral hepatitis.
消除病毒性肝炎的策略正处于关键阶段，需要对全球发病率趋势进行最新评估。
四种急性病毒性肝炎（AVH），即甲型急性肝炎（AHA）、乙型急性肝炎（AHB）、丙型急性肝炎（AHC）和戊型急性肝炎（AHE）的发病率数据来源于《2021年全球疾病负担（GBD）研究》。年度百分比变化用于阐明时间趋势，而健康不平等和前沿分析则用于评估全球健康公平性并量化各国之间的负担差异。
2021年，全球AVH的估计发病率如下：AHA（1.6086亿）、AHB（6353万）、AHE（1937万）和AHC（701万）。2000年至2021年，四种类型AVH的年龄标准化发病率（ASIR）呈下降趋势，其中AHB下降最为显著。预计在未来15年中，AHA、AHB和AHC的发病率将继续下降；然而，AHE的发病率预计将上升。2021年，AVH的发病率与社会人口指数（SDI）呈显著负相关，但国家之间的健康差距有所缩小。消除AHB潜力最高的国家主要位于低和中低SDI地区，而AHA的则集中在高和中高SDI地区。此外，AHC和AHE差异最大的国家分布较为分散。
尽管全球AVH发病率在下降，但它仍然是一项严峻的公共卫生挑战。减少健康差距对于消除病毒性肝炎至关重要。
