Dogterom A A, Huber-Bruning O, Vernooy J E, Wilbrink B, den Otter W, Huber J
Rheumatol Int. 1985;5(4):169-73. doi: 10.1007/BF00541518.
Human articular cartilage of different ages was cultured for 8 days and proteoglycan (PG) release into the medium was measured. Retinol and synovial co-culture increased the PG release of cartilage of all ages. The effect of retinol was dose-dependent. Synovium increased also the PG release of dead cartilage, whereas retinol did not. The increased PG release by synovial co-culture is therefore mainly the result of synovial enzymes acting directly on the matrix rather than of a factor inducing chondrocyte-mediated breakdown.
将不同年龄的人关节软骨培养8天，并测量蛋白聚糖（PG）向培养基中的释放量。视黄醇和滑膜共培养增加了各年龄段软骨的PG释放。视黄醇的作用呈剂量依赖性。滑膜也增加了死亡软骨的PG释放，而视黄醇则没有。因此，滑膜共培养导致的PG释放增加主要是滑膜酶直接作用于基质的结果，而不是诱导软骨细胞介导的分解的因素所致。
