淋巴细胞通过产生分解代谢素诱导软骨吸收。
Lymphocytes induce resorption of cartilage by producing catabolin.
作者信息
Saklatvala J, Sarsfield S J
出版信息
Biochem J. 1982 Jan 15;202(1):275-8. doi: 10.1042/bj2020275.
Abstract
Mononuclear cells from pig blood, when cultured in the presence of lectins (concanavalin A or phytohaemagglutinin), release a factor that induces resorption of proteoglycan in explants of live bovine nasal cartilage. The factor had mol.wt. 20000 and pI 4.6-5.0, and was indistinguishable from the cartilage-catabolic protein catabolin isolated from culture medium of explants of pig synovial tissue. Since much of the catabolin from the mononuclear cells arose from the non-adherent population (98% lymphocytes) it was concluded that lymphocytes (and possibly monocytes) make catabolin.
摘要
猪血中的单核细胞在凝集素（刀豆球蛋白A或植物血凝素）存在的情况下进行培养时，会释放出一种因子，该因子可诱导活牛鼻软骨外植体中的蛋白聚糖发生吸收。该因子的分子量为20000，等电点为4.6 - 5.0，与从猪滑膜组织外植体培养基中分离出的软骨分解蛋白分解素无法区分。由于单核细胞产生的大部分分解素来自非贴壁细胞群（98%为淋巴细胞），因此得出结论，淋巴细胞（可能还有单核细胞）会产生分解素。
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3
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