Liu Shichao, Tai Zhiyuan, Li Muzhi, Zhang Rui, Shao Guobin, Guo Jiatai, Lu Weixing
Northeast Agricultural University, Harbin, 150030, China.
Heilongjiang University, Harbin, 150080, China.
Trop Anim Health Prod. 2025 Jun 9;57(5):252. doi: 10.1007/s11250-025-04490-9.
The research aimed to evaluate how incorporating NAG and Trp into a low-protein diet affects intestinal functions and alterations in the microbiota, ultimately focusing on enhancing the growth and stress resistance of weaned piglets aged 3-4 weeks.A total of 120 weaned piglets were categorized into five distinct groups: a control group (CON), a low-protein diet group (LP), a low-protein diet group with 0.2% N-acetylglutamic acid (LP + NAG), a low-protein diet group with 0.2% tryptophan (LP + Trp), and a low-protein diet group with 0.2% N-acetylglutamic acid and 0.2% tryptophan (LP + NAG + Trp). The results revealed that the LP + NAG + Trp group exhibited a higher feed-to-gain ratio and improved growth performance, with significantly greater average daily gain and feed intake than the control group. Antioxidant capacity was enhanced, as indicated by elevated levels of catalase and glutathione peroxidase. The expression of tight junction proteins ZO-1 and claudin-1 increased, strengthening the intestinal barrier. Additionally, immunoglobulin levels and the abundance of actinomycetes in the gut microbiota rose, indicating improved immune function and gut health.The increased digestive capacity of the intestine may be linked to the growth in the population of actinomycetes, which is attributed to the combined addition of the NAG + Trp group.
该研究旨在评估将N-乙酰谷氨酸（NAG）和色氨酸（Trp）添加到低蛋白日粮中如何影响肠道功能和微生物群的变化，最终聚焦于提高3至4周龄断奶仔猪的生长性能和抗应激能力。总共120头断奶仔猪被分为五个不同的组：对照组（CON）、低蛋白日粮组（LP）、添加0.2% N-乙酰谷氨酸的低蛋白日粮组（LP+NAG）、添加0.2%色氨酸的低蛋白日粮组（LP+Trp）以及添加0.2% N-乙酰谷氨酸和0.2%色氨酸的低蛋白日粮组（LP+NAG+Trp）。结果显示，LP+NAG+Trp组的料重比更低，生长性能得到改善，平均日增重和采食量显著高于对照组。过氧化氢酶和谷胱甘肽过氧化物酶水平升高表明抗氧化能力增强。紧密连接蛋白ZO-1和claudin-1的表达增加，强化了肠道屏障。此外，肠道微生物群中免疫球蛋白水平和放线菌丰度升高，表明免疫功能和肠道健康得到改善。肠道消化能力的提高可能与放线菌数量的增加有关，这归因于NAG+Trp组的联合添加。
