Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Graefes Arch Clin Exp Ophthalmol. 2020 Aug;258(8):1779-1785. doi: 10.1007/s00417-020-04644-5. Epub 2020 Apr 4.
To determine the relationship between the peripapillary choroidal thickness (ppCT) and the degree and distribution of the tessellation in the fundus of normal eyes.
This was a prospective, observational cross-sectional study of 118 right eyes of young healthy volunteers. The ppCT was measured from the optical coherence tomography (OCT) circle scans manually at eight sectors: the nasal, supranasal superior, supratemporal, temporal, infratemporal, inferior, and infranasal sectors. The subjective degree of the tessellation in the color fundus photographs (CFPs) was classified into three categories: non-tessellated (NT), weakly tessellated (WT), and strongly tessellated (ST) in same sectors. The objective degree of tessellation designated by the tessellation fundus index (TFI) which was calculated as TFI = (R - G)/(R + G + B) using the mean value of the red-green-blue intensities of the CFPs. The differences in the ppCT and TFI for the three tessellation groups were analyzed. The correlations between the TFI and the ppCT were also determined.
The mean age of the subjects was 25.8 years and the mean axial length of the eye was 25.5 mm. The inter-rater agreement of the subjective classifications was high with a Fleiss kappa of 0.71. The ppCT was significantly thinner in eyes with higher degrees of tessellation (P < 0.05) in all sectors. The TFIs were significantly and negatively correlated with the ppCTs in all sectors (r = - 0.44 to - 0.24, P < 0.05) except the nasal and the supranasal sectors.
The degree of peripapillary tessellation is significantly correlated with the ppCT in young healthy eyes, and it has large individual and geographic variations.
确定正常眼周边脉络膜厚度（ppCT）与眼底镶嵌程度和分布的关系。
这是一项前瞻性、观察性的横断面研究，纳入了 118 名年轻健康志愿者的 118 只右眼。通过手动从光学相干断层扫描（OCT）环扫中测量 8 个象限的 ppCT：鼻侧、鼻上、颞上、颞侧、颞下、下侧和鼻下象限。眼底彩色照片（CFPs）中主观镶嵌程度分为 3 类：无镶嵌（NT）、弱镶嵌（WT）和强镶嵌（ST），在同一象限中分类。通过 CFPs 的红-绿-蓝强度的平均值计算出镶嵌眼底指数（TFI）来客观地表示镶嵌程度，TFI 定义为 TFI=（R-G）/（R+G+B）。分析了 3 个镶嵌组之间的 ppCT 和 TFI 差异。还确定了 TFI 与 ppCT 之间的相关性。
受试者的平均年龄为 25.8 岁，眼轴平均长度为 25.5mm。主观分类的观察者间一致性很高，Fleiss κ 值为 0.71。在所有象限中，镶嵌程度较高的眼的 ppCT 明显较薄（P<0.05）。TFIs 与所有象限的 ppCT 呈显著负相关（r=-0.44 至-0.24，P<0.05），除了鼻侧和鼻上象限。
在年轻健康的眼中，周边脉络膜镶嵌的程度与 ppCT 显著相关，并且具有较大的个体和地域差异。
