Alraddadi Wejdan Hassan, Alsulami Yara Faraj, Alsubhi Aseel Abdulrahim, Almabouth Anhar Saleh, Aljahdali Esraa Abdulrahman, Sabbagh Heba Jafar
Ministry of Health, Al Madinah, Saudi Arabia.
King Abdulaziz University, University Dental Hospital, Jeddah, Saudi Arabia.
Saudi Dent J. 2025 Jun 9;37(4-6):17. doi: 10.1007/s44445-025-00020-3.
Molar Incisor Hypomineralization (MIH) is a developmental enamel defect that affects permanent first molars (PFMs) and incisors, leading to caries and early tooth loss. This systematic review investigates the literature for the relationship between stress-related factors and the occurrence of MIH. A comprehensive literature search was conducted across PubMed, Cochrane, Scopus, Google Scholar, and BASE. Articles were screened and data extracted using the Rayyan platform for systematic reviews. The quality of the included studies was assessed using the Newcastle-Ottawa Scale (NOS). Six-studies were included, five examined maternal stress during pregnancy while one on stress experienced during early childhood. Out of them, five reported a significant association between stress and MIH. Given the significant variability in stress assessment methods across studies, we were able to include only two studies in the meta-analysis. Although not statistically significant, the meta-analysis showed a tendency for increased odds of MIH in the presence of stress, with an overall odds ratio of 1.46 (95% CI: 0.66-3.22). These findings suggest a potential association between psychological stress and MIH. However, further research is needed to confirm these results and elucidate the mechanisms involved. Addressing current research limitations will improve study reliability and inform preventive strategies to reduce maternal and early childhood stress, potentially mitigating MIH prevalence.
磨牙切牙矿化不全（MIH）是一种发育性牙釉质缺陷，会影响恒牙第一磨牙（PFMs）和切牙，导致龋齿和早期牙齿脱落。本系统评价调查了与压力相关因素和MIH发生之间关系的文献。在PubMed、Cochrane、Scopus、谷歌学术和BASE数据库中进行了全面的文献检索。使用Rayyan系统评价平台对文章进行筛选和数据提取。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。纳入了六项研究，五项研究考察了孕期母亲的压力，一项研究考察了幼儿期经历的压力。其中，五项研究报告了压力与MIH之间存在显著关联。鉴于各研究中压力评估方法存在显著差异，我们仅能将两项研究纳入荟萃分析。尽管无统计学意义，但荟萃分析显示在有压力的情况下MIH发生几率有增加的趋势，总体比值比为1.46（95%CI：0.66 - 3.22）。这些发现提示心理压力与MIH之间可能存在关联。然而，需要进一步研究来证实这些结果并阐明其中涉及的机制。解决当前的研究局限性将提高研究的可靠性，并为减少母亲和幼儿期压力的预防策略提供依据，从而有可能降低MIH的患病率。
