Denzlinger C, Rapp S, Hagmann W, Keppler D
Science. 1985 Oct 18;230(4723):330-2. doi: 10.1126/science.4048937.
A significant increase in the production of cysteinyl leukotrienes was observed after mechanical or thermal trauma in the anesthesized rat. The amount of biliary N-acetyl-leukotriene E4, which represents a suitable indicator for blood plasma leukotrienes, was used as a measure of leukotriene generation. Cysteinyl leukotrienes were rapidly eliminated from blood plasma into bile where N-acetyl-leukotriene E4 was the major metabolite. Leukotrienes were at a much lower concentration in blood plasma than in bile and differed in the pattern of metabolites. The detected amounts of leukotrienes were sufficient to induce known phenomena associated with trauma, such as tissue edema and circulatory and respiratory dysfunction. Increased leukotriene generation appears to play an important role in the pathophysiology of tissue trauma.
在麻醉大鼠中，机械性或热性创伤后观察到半胱氨酰白三烯的生成显著增加。胆汁中N-乙酰白三烯E4的量可作为血浆白三烯的合适指标，用于衡量白三烯的生成。半胱氨酰白三烯从血浆迅速排入胆汁，其中N-乙酰白三烯E4是主要代谢产物。白三烯在血浆中的浓度远低于胆汁，且代谢产物模式不同。检测到的白三烯量足以诱发与创伤相关的已知现象，如组织水肿以及循环和呼吸功能障碍。白三烯生成增加似乎在组织创伤的病理生理学中起重要作用。
