局部使用 Rectogesic® 和 Emla® 改善热损伤后的皮肤血液灌注。一项对比实验研究。
Topical use of Rectogesic® and Emla® to improve cutaneous blood perfusion following thermal injury. A comparative experimental study.
作者信息
Tagkalakis P, Dionyssopoulos A, Karkavelas G, Demiri E
机构信息
Department of Plastic Surgery, Medical School, Aristotle University of Thessaloniki, General Hospital of Thessaloniki "G. Papageorgiou", Thessaloniki, Greece.
Department of Pathology, Medical School, Aristotle University of Thessaloniki, General Hospital of Thessaloniki "G. Papageorgiou", Thessaloniki, Greece.
出版信息
Ann Burns Fire Disasters. 2015 Jun 30;28(2):134-41.
Early post-burn ischemic necrosis of the skin is of particular interest in modern burn research. The purpose of this study was to test the hypothesis that blood perfusion could be improved by the topical application of vasoactive substances. A sample of 55 wistar rats was used to investigate the effect of 0,4% nitroglycerin ointment (Rectogesic(®)) comparatively to no application and placebo. The beneficiary action of 5% prilocaine/lidocaine cream (EMLA(®)) in burn blood perfusion was also tested comparatively to Rectogesic(®). Both preparations were tested respectively to non burned controls. Laser Doppler assessment of blood flow at 15, 30, 45, 60, 120 and 180 minutes after preparation application, demonstrated that the use of Rectogesic(®) improved perfusion at all measurements compared to placebo and to no preparation application (p&0,05). There was no statistical significant difference in the effect of the two preparations.
烧伤后早期皮肤缺血性坏死是现代烧伤研究中特别受关注的问题。本研究的目的是检验局部应用血管活性物质可改善血液灌注这一假设。使用55只Wistar大鼠样本，比较0.4%硝酸甘油软膏（Rectogesic®）不应用和应用安慰剂的效果。还比较了5%丙胺卡因/利多卡因乳膏（EMLA®）与Rectogesic®对烧伤血液灌注的有益作用。两种制剂分别在未烧伤的对照上进行测试。在制剂应用后15、30、45、60、120和180分钟用激光多普勒评估血流，结果表明，与安慰剂和不应用制剂相比，使用Rectogesic®在所有测量中均改善了灌注（p<0.05）。两种制剂的效果无统计学显著差异。
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