Guthaner D F, Silverman J F, Hayden W G, Wexler L
AJR Am J Roentgenol. 1977 May;128(5):737-9. doi: 10.2214/ajr.128.5.737.
A pilot study involving 36 patients was undertaken to test the efficacy of combining 1% lidocaine with 60% methylglucamine iothalamate for relief of the severe burning pain often experienced during peripheral arteriography. Of 24 patients premedicated with meperidine hydrochloride and promethazine hydrochloride, 12 received lidocaine with the contrast medium and 12 did not. The remaining 12 patients were premedicated with diazepam and received lidocaine with the contrast material. By both subjective and objective criteria, those patients receiving lidocaine in the intraarterial injection of contrast medium suffered less pain. Optimum results were achieved for the lidocaine group receiving analgesic premedication. No adverse reactions attributable to the lidocaine were encountered. Subsequent to completion of the pilot study, more than 300 patients have been studied with similar impressive results of pain relief and safety.
开展了一项涉及36例患者的初步研究，以测试1%利多卡因与60%碘他拉葡胺联合使用缓解外周动脉造影术期间经常出现的严重灼痛的疗效。在24例用盐酸哌替啶和盐酸异丙嗪进行术前用药的患者中，12例在造影剂中加入利多卡因，12例未加。其余12例患者用安定进行术前用药，并在造影剂中加入利多卡因。根据主观和客观标准，那些在动脉内注射造影剂时接受利多卡因的患者疼痛较轻。接受镇痛术前用药的利多卡因组取得了最佳效果。未遇到可归因于利多卡因的不良反应。在初步研究完成后，已对300多名患者进行了研究，在缓解疼痛和安全性方面取得了类似的令人印象深刻的结果。
