Lanz E, Günther R
Anaesthesist. 1978 Jul;27(7):325-8.
45% contrast medium, to which lignocaine had been added in a concentration of 0.1%, was injected for 44 translumbar aortograms, 26 femoral arteriograms and 4 brachial arteriograms under premedication with pethidine-promethazine. Few patients described their sensations spontaneously; most patients graded their pain as minimal and described only the sensation of heat. When the contrast medium was injected, first without and then with lignocaine, the pain was markedly reduced by lignocaine. No patient showed signs of CNS-toxicity. After the injection of the mixture of contrast medium and lignocaine, the heart rate rose slightly, the arterial blood pressure fell slightly, both not more than after injection of the contrast medium only. The ECG showed no anomalies. The addition of lignocaine to a contrast medium in low concentration represents a simple and, for the patient, acceptable method of analgesia as well as a safe alternative to general, spinal or epidural anesthesia.
在哌替啶 - 异丙嗪进行术前用药的情况下，对44例经腰主动脉造影、26例股动脉造影和4例肱动脉造影患者注射了添加了浓度为0.1%利多卡因的45%造影剂。很少有患者自发描述他们的感觉；大多数患者将疼痛程度评为轻微，仅描述有热感。当先不添加利多卡因、然后添加利多卡因注射造影剂时，利多卡因可明显减轻疼痛。没有患者出现中枢神经系统毒性迹象。注射造影剂和利多卡因的混合物后，心率略有上升，动脉血压略有下降，两者变化均不超过仅注射造影剂后的变化。心电图未显示异常。在造影剂中添加低浓度利多卡因是一种简单且患者可接受的镇痛方法，也是全身麻醉、脊髓麻醉或硬膜外麻醉的安全替代方法。
